Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/20621
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Visceral adiposity is not associated with abdominal aortic aneurysm presence and growth
Authors: Cronin, Oliver
Liu, David
Bradshaw, Barbara
Iyer, Vikram
Buttner, Petra
Cunningham, Margaret
Walker, Philip J
Golledge, Jonathan
Contact Email: margaret.cunningham@stir.ac.uk
Keywords: abdominal aortic aneurysm
adiposity
obesity
visceral
Issue Date: Aug-2014
Publisher: SAGE
Citation: Cronin O, Liu D, Bradshaw B, Iyer V, Buttner P, Cunningham M, Walker PJ & Golledge J (2014) Visceral adiposity is not associated with abdominal aortic aneurysm presence and growth, Vascular Medicine, 19 (4), pp. 272-280.
Abstract: Previous studies in rodent models and patients suggest that visceral adipose could play a direct role in the development and progression of abdominal aortic aneurysm (AAA). This study aimed to assess the association of visceral adiposity with AAA presence and growth. This study was a case-control investigation of patients that did (n=196) and did not (n=181) have an AAA who presented to The Townsville Hospital vascular clinic between 2003 and 2012. Cases were patients with AAA (infra-renal aortic diameter >30 mm) and controls were patients with intermittent claudication but no AAA (infra-renal aortic diameter <30 mm). All patients underwent computed tomography angiography (CTA). The visceral to total abdominal adipose volume ratio was estimated from CTAs by assessing total and visceral adipose deposits using an imaging software program. Measurements were assessed for reproducibility by repeat assessments on 15 patients. AAA risk factors were recorded at entry. Forty-five cases underwent two CTAs more than 6 months apart to assess AAA expansion. The association of visceral adiposity with AAA presence and growth was examined using logistic regression. Visceral adipose assessment by CTA was highly reproducible (mean coefficient of variation 1.0%). AAA was positively associated with older age and negatively associated with diabetes. The visceral to total abdominal adipose volume ratio was not significantly associated with AAA after adjustment for other risk factors. Patients with a visceral to total abdominal adipose volume ratio in quartile four had a 1.63-fold increased risk of AAA but with wide confidence intervals (95% CI 0.71-3.70; p=0.248). Visceral adiposity was not associated with AAA growth. In conclusion, this study suggests that visceral adiposity is not specifically associated with AAA presence or growth although larger studies are required to confirm these findings.
Type: Journal Article
URI: http://hdl.handle.net/1893/20621
DOI Link: http://dx.doi.org/10.1177/1358863X14537883
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: James Cook University
James Cook University
James Cook University
James Cook University
James Cook University
Psychology
James Cook University
James Cook University

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