Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/19636
Appears in Collections:Biological and Environmental Sciences Journal Articles
Peer Review Status: Refereed
Title: Novel adenoviruses in wild primates: a high level of genetic diversity and evidence of zoonotic transmissions
Authors: Wevers, Diana
Metzger, Sonja
Babweteera, Fred
Bieberbach, Marc
Boesch, Christophe
Cameron, Kenneth
Couacy-Hymann, Emmanuel
Cranfield, Mike
Gray, Maryke
Harris, Laurie A
Head, Josephine
Jeffery, Kathryn Jane
Knauf, Sascha
Lankester, Felix
Leendertz, Siv Aina J
Contact Email: kathryn.jeffery1@stir.ac.uk
Issue Date: Oct-2011
Publisher: American Society for Microbiology
Citation: Wevers D, Metzger S, Babweteera F, Bieberbach M, Boesch C, Cameron K, Couacy-Hymann E, Cranfield M, Gray M, Harris LA, Head J, Jeffery KJ, Knauf S, Lankester F & Leendertz SAJ (2011) Novel adenoviruses in wild primates: a high level of genetic diversity and evidence of zoonotic transmissions, Journal of Virology, 85 (20), pp. 10774-10784.
Abstract: Adenoviruses (AdVs) broadly infect vertebrate hosts, including a variety of nonhuman primates (NHPs). In the present study, we identified AdVs in NHPs living in their natural habitats, and through the combination of phylogenetic analyses and information on the habitats and epidemiological settings, we detected possible horizontal transmission events between NHPs and humans. Wild NHPs were analyzed with a pan-primate AdV-specific PCR using a degenerate nested primer set that targets the highly conserved adenovirus DNA polymerase gene. A plethora of novel AdV sequences were identified, representing at least 45 distinct AdVs. From the AdV-positive individuals, 29 nearly complete hexon genes were amplified and, based on phylogenetic analysis, tentatively allocated to all known human AdV species (Human adenovirus A to Human adenovirus G [HAdV-A to -G]) as well as to the only simian AdV species (Simian adenovirus A [SAdV-A]). Interestingly, five of the AdVs detected in great apes grouped into the HAdV-A, HAdV-D, HAdV-F, or SAdV-A clade. Furthermore, we report the first detection of AdVs in New World monkeys, clustering at the base of the primate AdV evolutionary tree. Most notably, six chimpanzee AdVs of species HAdV-A to HAdV-F revealed a remarkably close relationship to human AdVs, possibly indicating recent interspecies transmission events.
Type: Journal Article
URI: http://hdl.handle.net/1893/19636
DOI Link: http://dx.doi.org/10.1128/JVI.00810-11
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Notes: Additional co-authors: Elizabeth Lonsdorf, Lawrence Mugisha, Andreas Nitsche, Patricia Reed, Martha Robbins, Dominic A. Travis, Zinta Zommers, Fabian H. Leendertz and Bernhard Ehlers
Affiliation: Robert Koch Institute
Robert Koch Institute
Budongo Conservation Field Station
Robert Koch Institute
University Leipzig
Wildlife Conservation Society (Africa Program)
Laboratoire National d'Appui au Développement Agricole - LANADA (Laborotoire Central de la Pathologie Animale)
Mountain Gorilla Veterinary Project
International Gorilla Conservation Programme
University of California, Davis
Max Planck Institute for Evolutionary Anthropology
Biological and Environmental Sciences
German Primate Center
Lincoln Park Zoo
Robert Koch Institute

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