Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/19305
Appears in Collections:Biological and Environmental Sciences Journal Articles
Peer Review Status: Refereed
Title: Diverse Immune Functions of Hemocyanins
Authors: Coates, Christopher
Nairn, Jacqueline
Contact Email: c.j.coates@stir.ac.uk
Keywords: Multifunctional
Hemocyanin
Phenoloxidase
Microbicidal
Innate immunity
Hemoglobin
Issue Date: Jul-2014
Publisher: Elsevier
Citation: Coates C & Nairn J (2014) Diverse Immune Functions of Hemocyanins, Developmental and Comparative Immunology, 45 (1), pp. 43-55.
Abstract: Substantial evidence gathered recently has revealed the multiple functionalities of hemocyanin. Contrary to previous claims that this ancient protein is involved solely in oxygen transport within the hemolymph of invertebrates, hemocyanin and hemocyanin-derived peptides have been linked to key aspects of innate immunity, in particular, antiviral and phenoloxidase-like activities. Both phenoloxidase and hemocyanin belong to the family of type-3 copper proteins and share a high degree of sequence homology. While the importance of phenoloxidase in immunity and development is well characterised, the contribution of hemocyanin to biological defence systems within invertebrates is not recognised widely. This review focusses on the conversion of hemocyanin into a phenoloxidase-like enzyme and the array of hemocyanin-derived immune responses documented to date.
Type: Journal Article
URI: http://hdl.handle.net/1893/19305
DOI Link: http://dx.doi.org/10.1016/j.dci.2014.01.021
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Biological and Environmental Sciences
Biological and Environmental Sciences

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