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Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Dual Task Performance in early Alzheimer's disease, amnestic mild cognitive impairment and depression
Authors: Lonie, Jane A
Tierney, Kevin M
Herrmann, Lucie L
Donaghey, Claire
O'Carroll, Ronan
Lee, Andrew
Ebmeier, Klaus P
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Keywords: Neuropsychology
Geriatric Assessment
Memory Disorders
Depressive Disorder
Depressive Disorder, Major
Dysthymic Disorder
Issue Date: Jan-2009
Publisher: Cambridge University Press
Citation: Lonie JA, Tierney KM, Herrmann LL, Donaghey C, O'Carroll R, Lee A & Ebmeier KP (2009) Dual Task Performance in early Alzheimer's disease, amnestic mild cognitive impairment and depression, Psychological Medicine, 39 (1), pp. 23-31.
Abstract: Background: The dual task paradigm (Baddeley et al., 1986; Della Sala et al., 1995) has been proposed as a sensitive measure of Alzheimer’s disease, early in the disease process. Methods: We investigated this claim by administering the modified dual task paradigm (utilising a pencil and paper version of a tracking task) to 38 patients with amnestic Mild Cognitive Impairment (aMCI) and 10 with early Alzheimer’s disease, as well as 21 healthy elderly subjects and 17 controls with depressive symptoms. All groups were closely matched for age and pre-morbid intellectual ability. Results: There were no group differences in dual task performance, despite poor performance in episodic memory tests of the aMCI and early Alzheimer’s disease groups. In contrast, early Alzheimer’s disease and depressed patients were impaired in Part B of Trail Making Test, another commonly used measure of divided attention. Conclusions: The dual task paradigm lacks sensitivity for use in the early differential diagnosis of Alzheimer’s disease.
Type: Journal Article
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Rights: Published in Psychological Medicine. Copyright: Cambridge University Press. This paper has been accepted for publication and will appear in a revised form, subsequent to editorial input by Cambridge University Press, in Psychological Medicine, Volume 39, Issue 1, January 2009, pp. 23 - 31, published by Cambridge University Press, Copyright © 2008 Cambridge University Press.;
Affiliation: Royal Edinburgh Hospital
University of Edinburgh
University of Edinburgh
Royal Edinburgh Hospital
Royal Edinburgh Hospital
Royal Edinburgh Hospital

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