|Appears in Collections:||Psychology Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Animal models of working memory: a review of tasks that might be used in screening drug treatments for the memory impairments found in schizophrenia|
Baxter, Mark G
Delayed non-matching to position
|Citation:||Dudchenko P, Talpos J, Young J & Baxter MG (2013) Animal models of working memory: a review of tasks that might be used in screening drug treatments for the memory impairments found in schizophrenia, Neuroscience and Biobehavioral Reviews, 37 (9, Part B), pp. 2111-2124.|
|Abstract:||The Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) meeting on "Selecting Promising Animal Paradigms" focused on a consideration of valid tasks for drug discovery in non-humans. This review is based on a break-out session with experts from academia and industry which considered tasks that tap working memory in animals. The specific focus of session was on tasks measuring goal maintenance, memory capacity, and interference control. Of the tasks nominated for goal maintenance, the most developed paradigms were operant delayed-non-matching-to-position tasks, and touch-screen variants of these may hold particular promise. For memory capacity, the task recommended for further development was the span task, although it is recognized that more work on its neural substrates is required. For interference control, versions of the n-back task were felt to resemble the deficits found in schizophrenia, although additional development of these tasks is also required.|
|Rights:||The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.|
Johnson & Johnson
University of California
Mount Sinai School of Medicine
|Dudchenko_etal_N&BR_2013.pdf||989.22 kB||Adobe PDF||Under Embargo until 31/12/2999 Request a copy|
Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependant on the depositor still being contactable at their original email address.
This item is protected by original copyright
Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
If you believe that any material held in STORRE infringes copyright, please contact email@example.com providing details and we will remove the Work from public display in STORRE and investigate your claim.