|Appears in Collections:||Computing Science and Mathematics Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Population-based optimization of cytostatic/cytotoxic combination cancer chemotherapy|
Particle swarm optimization
|Citation:||Ochoa G & Villasana M (2013) Population-based optimization of cytostatic/cytotoxic combination cancer chemotherapy, Soft Computing, 17 (6), pp. 913-924.|
|Abstract:||This article studies the suitability of modern population based algorithms for designing combination cancer chemotherapies. The problem of designing chemotherapy schedules is expressed as an optimization problem (an optimal control problem) where the objective is to minimize the tumor size without compromising the patient's health. Given the complexity of the underlying mathematical model describing the tumor's progression (considering two types of drugs, the cell cycle and the immune system response), analytical and classical optimization methods are not suitable, instead, stochastic heuristic optimization methods are the right tool to solve the optimal control problem. Considering several solution quality and performance metrics, we compared three powerful heuristic algorithms for real-parameter optimization, namely, CMA evolution strategy, differential evolution, and particle swarm pattern search method. The three algorithms were able to successfully solve the posed problem. However, differential evolution outperformed its counterparts both in quality of the obtained solutions and efficiency of search.|
|Rights:||The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.|
|Affiliation:||Computing Science - CSM Dept|
Universidad Simon Bolivar
|evolchemo.pdf||502.77 kB||Adobe PDF||Under Embargo until 31/12/2999 Request a copy|
Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependant on the depositor still being contactable at their original email address.
This item is protected by original copyright
Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
If you believe that any material held in STORRE infringes copyright, please contact firstname.lastname@example.org providing details and we will remove the Work from public display in STORRE and investigate your claim.