Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/10306
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: A single photon emission computerised tomography study of regional brain function in elderly patients with major depression and with Alzheimer-type dementia
Authors: Curran, S M
Murray, Caroline M
Van, Beck Margaret
Dougall, Nadine
O'Carroll, Ronan
Austin, Marie-Paule
Ebmeier, Klaus P
Goodwin, Guy M
Contact Email: ronan.ocarroll@stir.ac.uk
Issue Date: Aug-1993
Publisher: The Royal College of Psychiatrists
Citation: Curran SM, Murray CM, Van Beck M, Dougall N, O'Carroll R, Austin M, Ebmeier KP & Goodwin GM (1993) A single photon emission computerised tomography study of regional brain function in elderly patients with major depression and with Alzheimer-type dementia, British Journal of Psychiatry, 163 (2), pp. 155-165.
Abstract: The uptake, at rest, of 99mTc-exametazime into different brain regions was compared using SPECT for 20 elderly subjects with major depressive disorder, 20 with Alzheimer-type dementia, and 30 age-matched normal volunteers. Uptake was referred to calcarine-occipital cortex as a reference sensory area. Cross-sectional differences between the three groups were highly statistically significant, but reflected primarily the reductions in cortical uptake in the Alzheimer group. A detailed comparison of depressed patients and controls identified decrements in anterior cingulate, temporal and frontal cortex and in caudate and thalamus in men only. These decrements were correlated with impairment of performance on a trail-making task, but were also associated with continuing treatment with antidepressants or benzodiazepines. However, most depressed patients had quantitatively normal scans for posterior parietal association cortex, and this suggests that SPECT may find a limited role in the differential diagnosis of depression and dementia. The reduced brain function in some depressed patients may parallel the findings from studies of brain structure in elderly depressives; there was between good outcome at 6-18 months and increased tracer uptake in subcortical areas.
Type: Journal Article
URI: http://hdl.handle.net/1893/10306
DOI Link: http://dx.doi.org/10.1192/bjp.163.2.155
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Royal Edinburgh Hospital
Royal Edinburgh Hospital
Royal Edinburgh Hospital
NMAHP Research
Psychology
Royal Edinburgh Hospital
Royal Edinburgh Hospital
Royal Edinburgh Hospital

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