Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/10097
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Cerebral perfusion correlates of depressed mood
Authors: Ebmeier, Klaus P
Cavanagh, Jonathan T O
Moffoot, Anthony P R
Glabus, Michael F
O'Carroll, Ronan
Goodwin, Guy M
Contact Email: ronan.ocarroll@stir.ac.uk
Issue Date: Jan-1997
Publisher: The Royal College of Psychiatrists
Citation: Ebmeier KP, Cavanagh JTO, Moffoot APR, Glabus MF, O'Carroll R & Goodwin GM (1997) Cerebral perfusion correlates of depressed mood, British Journal of Psychiatry, 170 (1), pp. 77-81.
Abstract: BACKGROUND The spontaneous diurnal variation of mood and other symptoms provides a substrate for the examination of the relationship between symptoms and regional brain activation in depression. METHOD Twenty unipolar depressed patients with diurnal variation of mood were examined at 8 a.m. and 8 p.m. with neuropsychological measures, clinical ratings and single photon emission tomography (SPET). Brain perfusion maps were spatially transformed into standard stereotactic space and compared pixel-by-pixel. A parametric (correlational) analysis was used to examine the relationship between symptom severity and brain perfusion, both between and within subjects. RESULTS Global depression severity and an independent 'vital' depression factor were associated in subjects with increased perfusion in cingulate and other paralimbic areas. In addition there was a probable association between an increase in an anxious-depression factor and reduced frontal neocortical perfusion. CONCLUSIONS Depressive symptom changes are associated with metabolic changes in the cingulate gyrus and associated paralimbic structures.
Type: Journal Article
URI: http://hdl.handle.net/1893/10097
DOI Link: http://dx.doi.org/10.1192/bjp.170.1.77
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Royal Edinburgh Hospital
University of Edinburgh
Royal Edinburgh Hospital
University of Edinburgh
Psychology
Royal Edinburgh Hospital

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