Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/10095
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: The neuropsychiatric sequelae of mercury poisoning. The Mad Hatter's disease revisited
Authors: O'Carroll, Ronan
Masterton, George
Dougall, Nadine
Ebmeier, Klaus P
Goodwin, Guy M
Contact Email: ronan.ocarroll@stir.ac.uk
Issue Date: Jul-1995
Publisher: The Royal College of Psychiatrists
Citation: O'Carroll R, Masterton G, Dougall N, Ebmeier KP & Goodwin GM (1995) The neuropsychiatric sequelae of mercury poisoning. The Mad Hatter's disease revisited, British Journal of Psychiatry, 167 (1), pp. 95-98.
Abstract: BACKGROUND The detailed effects of mercury poisoning on cognitive function, brain anatomy and regional brain function are largely unknown. We report the case of a 38-year-old man who was exposed to toxic levels of inorganic mercury. METHOD Four years after exposure, the patient was assessed using magnetic resonance imaging (MRI), single-photon emission computerised tomography (SPECT) and detailed neuropsychological evaluation. RESULTS The patient developed a myriad of physical and psychiatric complaints, including stomatitis, muscle spasm, tremor, skin rash and the psychiatric syndrome known as 'erythism' (Mad Hatter's disease). Neuropsychological evaluation revealed marked and significant deficits of attention concentration, particularly when under time pressure. The MRI scan was unremarkable; however, SPECT revealed hypermetabolism of the posterior cingulate CONCLUSIONS Mercury poisoning appeared to result in a dysregulation of posterior cingulate cortex, which was associated with attention/concentration deficits and marked anxiety/agitation.
Type: Journal Article
URI: http://hdl.handle.net/1893/10095
DOI Link: http://dx.doi.org/10.1192/bjp.167.1.95
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Psychology
Royal Infirmary of Edinburgh
NMAHP Research
Royal Edinburgh Hospital
University of Oxford

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