Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/9865
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dc.contributor.authorWitard, Oliveren_UK
dc.contributor.authorTurner, James Een_UK
dc.contributor.authorJackman, Sarah Ren_UK
dc.contributor.authorTipton, Kevinen_UK
dc.contributor.authorJeukendrup, Asker Een_UK
dc.contributor.authorKies, Arie Ken_UK
dc.contributor.authorBosch, Jos Aen_UK
dc.date.accessioned2016-09-09T23:40:43Z-
dc.date.available2016-09-09T23:40:43Zen_UK
dc.date.issued2012-09en_UK
dc.identifier.urihttp://hdl.handle.net/1893/9865-
dc.description.abstractPurpose: We examined whether exercise-induced lymphocytosis and lymphocytopenia are impaired with high-intensity training. Methods: Eight trained cyclists (V˙O2max = 64.2 ± 6.5 mL·kg-1·min-1) undertook 1 wk of normal-intensity training and a second week of high-intensity training. On day 7 of each week, participants performed a cycling task, consisting of 120 min of submaximal exercise followed by a 45-min time trial. Blood was collected before, during, and after exercise. CD8+ T lymphocytes (CD8+TLs) were identified, as well as CD8+TL subpopulations on the basis of CD45RA and CD27 expression. Results: High-intensity training (18,577 ± 10,984 cells per microliter × ∼165 min) was associated with a smaller exercise-induced mobilization of CD8+TLs compared with normal-intensity training (28,473 ± 16,163 cells per microliter × ∼165 min, P = 0.09). The response of highly cytotoxic CD8+TLs (CD45RA+CD27-) to exercise was smaller after 1 wk of high-intensity training (3144 ± 924 cells per microliter × ∼165 min) compared with normal-intensity training (6417 ± 2143 cells per microliter × ∼165 min, P < 0.05). High-intensity training reduced postexercise CD8+TL lymphocytopenia (-436 ± 234 cells per microliter) compared with normal-intensity training (-630 ± 320 cells per microliter, P less than 0.05). This was driven by a reduced egress of naive CD8+TLs (CD27+CD45RA+). High-intensity training was associated with reduced plasma epinephrine (-37%) and cortisol (-15%) responses (P less than 0.05). Conclusions: High-intensity training impaired CD8+TL mobilization and egress in response to exercise. Highly cytotoxic CD8+TLs were primarily responsible for the reduced mobilization of CD8+TLs, which occurred in parallel with smaller neuroendocrine responses. The reduced capacity for CD8+TLs to leave blood after exercise with high-intensity training was accounted for primarily by naive, and also, highly cytotoxic CD8+TLs. This impaired CD8+TL redistribution in athletes undertaking intensified training may imply reduced immune surveillance.en_UK
dc.language.isoenen_UK
dc.publisherAmerican College of Sports Medicineen_UK
dc.relationWitard O, Turner JE, Jackman SR, Tipton K, Jeukendrup AE, Kies AK & Bosch JA (2012) High-Intensity Training Reduces CD8+ T-cell Redistribution in Response to Exercise. Medicine and Science in Sports and Exercise, 44 (9), pp. 1689-1697. https://doi.org/10.1249/MSS.0b013e318257d2dben_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.titleHigh-Intensity Training Reduces CD8+ T-cell Redistribution in Response to Exerciseen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31en_UK
dc.rights.embargoreason[witardetal_MSSE_2012.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1249/MSS.0b013e318257d2dben_UK
dc.citation.jtitleMedicine and Science in Sports and Exerciseen_UK
dc.citation.issn1530-0315en_UK
dc.citation.issn0195-9131en_UK
dc.citation.volume44en_UK
dc.citation.issue9en_UK
dc.citation.spage1689en_UK
dc.citation.epage1697en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailoliver.witard@stir.ac.uken_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationDSM Food Specialties, Delft, The Netherlandsen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.identifier.isiWOS:000307624600009en_UK
dc.identifier.scopusid2-s2.0-84865478872en_UK
dc.identifier.wtid750595en_UK
dc.contributor.orcid0000-0002-5875-8397en_UK
dc.contributor.orcid0000-0002-6545-8122en_UK
dcterms.dateAccepted2012-09-30en_UK
dc.date.filedepositdate2012-10-31en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorWitard, Oliver|0000-0002-5875-8397en_UK
local.rioxx.authorTurner, James E|en_UK
local.rioxx.authorJackman, Sarah R|en_UK
local.rioxx.authorTipton, Kevin|0000-0002-6545-8122en_UK
local.rioxx.authorJeukendrup, Asker E|en_UK
local.rioxx.authorKies, Arie K|en_UK
local.rioxx.authorBosch, Jos A|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2999-12-31en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenamewitardetal_MSSE_2012.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0195-9131en_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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