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dc.contributor.authorDesbois, Andrew Pen_UK
dc.contributor.authorCoote, Peter Jen_UK
dc.contributor.editorLaskin, AIen_UK
dc.contributor.editorSariaslani, Sen_UK
dc.contributor.editorGadd, GMen_UK
dc.description.abstractThere is an urgent need for new antimicrobial agents to combat infections caused by drug-resistant pathogens. Once a compound is shown to be effective in vitro, it is necessary to evaluate its efficacy in an animal infection model. Typically, this is achieved using a mammalian model, but such experiments are costly, time consuming, and require full ethical consideration. Hence, cheaper and ethically more acceptable invertebrate models of infection have been introduced, including the larvae of the greater wax moth Galleria mellonella. Invertebrates have an immune system that is functionally similar to the innate immune system of mammals, and often identical virulence and pathogenicity factors are used by human pathogenic microbes to infect wax moth larvae and mammals. Moreover, the virulence of many human pathogens is comparable in wax moth larvae and mammals. Using key examples from the literature, this chapter highlights the benefits of using the wax moth larva model to provide a rapid, inexpensive, and reliable evaluation of the toxicity and efficacy of new antimicrobial agents in vivo and prior to the use of more expensive mammalian models. This simple insect model can bridge the gap between in vitro studies and mammalian experimentation by screening out compounds with a low likelihood of success, while providing greater justification for further studies in mammalian systems. Thus, broader implementation of the wax moth larva model into anti-infective drug discovery and development programs could reduce the use of mammals during preclinical assessments and the overall cost of drug development.en_UK
dc.relationDesbois AP & Coote PJ (2012) Chapter 2 – Utility of greater wax moth larva (galleria mellonella) for evaluating the toxicity and efficacy of new antimicrobial agents. In: Laskin A, Sariaslani S & Gadd G (eds.) Advances in Applied Microbiology, Volume 78. Advances in Applied Microbiology, 78. Amsterdam: Elsevier, pp. 25-53.;
dc.relation.ispartofseriesAdvances in Applied Microbiology, 78en_UK
dc.rightsThe publisher has not responded to our queries therefore this work cannot be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectWax moth larvaen_UK
dc.subjectAntimicrobial agentsen_UK
dc.subjectMinimum inhibitory concentrationen_UK
dc.titleChapter 2 – Utility of greater wax moth larva (galleria mellonella) for evaluating the toxicity and efficacy of new antimicrobial agentsen_UK
dc.typePart of book or chapter of booken_UK
dc.rights.embargoreason[Desbois and Coote 2012.pdf] The publisher has not responded to our queries. This work cannot be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleAdvances in Applied Microbiologyen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.citation.btitleAdvances in Applied Microbiology, Volume 78en_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of St Andrewsen_UK
rioxxterms.typeBook chapteren_UK
local.rioxx.authorDesbois, Andrew P|0000-0001-6052-8761en_UK
local.rioxx.authorCoote, Peter J|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.contributorLaskin, AI|en_UK
local.rioxx.contributorSariaslani, S|en_UK
local.rioxx.contributorGadd, GM|en_UK
local.rioxx.filenameDesbois and Coote 2012.pdfen_UK
Appears in Collections:Aquaculture Book Chapters and Sections

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