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dc.contributor.authorTipton, Kevinen_UK
dc.contributor.authorWolfe, Robert Ren_UK
dc.description.abstractExercise has a profound acute effect on protein metabolism. Whereas reports on whole body responses to exercise have varied results, it is generally agreed leucine oxidation is increased during exercise, thus indicating increased net protein breakdown. Following endurance exercise, whole body protein breakdown is generally reduced from resting levels, while following eccentric exercise, both whole body protein breakdown and leucine oxidation are increased. Whole body protein synthesis, on the other hand, is either increased or unchanged. Much of the disagreement in the results of studies on the response of whole body protein metabolism to exercise may be attributed to the limitations of the available methods. Even if the methodology accurately reflects whole body metabolism, this may not reflect changes in the protein metabolism of muscle. Although endurance exercise has not been studied, muscle protein breakdown is increased following resistance exercise. There is a concomitant, and qualitatively greater, increase in muscle protein synthesis following resistance exercise, which may last for as long as 48 h. Increased muscle protein synthesis is linked to increased intramuscular availability of amino acids, and thus, to increased blood flow and increased amino acid delivery to the muscle, as well as increased amino acid transport. Administration of exogenous amino acids after exercise increases protein synthesis while ameliorating protein breakdown, thus improving net muscle protein balance. While it is clear that muscle protein synthesis and protein breakdown increase in a qualitatively similar manner following exercise, the mechanisms of stimulation have yet to be determined. However, we propose that the intracellular availability of amino acids is the link between these processes.en_UK
dc.publisherScandinavian Physiological Society/ John Wiley and Sonsen_UK
dc.relationTipton K & Wolfe RR (1998) Exercise-induced changes in protein metabolism. Acta Physiologica Scandinavica, 162 (3), pp. 377-387.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectprotein breakdownen_UK
dc.subjectprotein synthesisen_UK
dc.subjectstable isotopesen_UK
dc.titleExercise-induced changes in protein metabolismen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[j.1365-201X.1998.00306.x.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleActa Physiologica Scandinavicaen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Texasen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorTipton, Kevin|0000-0002-6545-8122en_UK
local.rioxx.authorWolfe, Robert R|en_UK
local.rioxx.projectInternal Project|University of Stirling|
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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