Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/8800
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dc.contributor.authorEvans, Josieen_UK
dc.contributor.authorMcGregor, Ellonen_UK
dc.contributor.authorMcMahon, Alex Den_UK
dc.contributor.authorMcGilchrist, Mark Men_UK
dc.contributor.authorJones, Martyn Cen_UK
dc.contributor.authorWhite, Gen_UK
dc.contributor.authorMcDevitt, Denis Gen_UK
dc.contributor.authorMacDonald, Thomas Men_UK
dc.date.accessioned2014-09-12T09:35:27Z-
dc.date.available2014-09-12T09:35:27Z-
dc.date.issued1995-08en_UK
dc.identifier.urihttp://hdl.handle.net/1893/8800-
dc.description.abstractNon-steroidal anti-inflammatory drugs (NSAIDs) have been implicated in the aetiology of acute renal failure (ARF), but epidemiological studies examining this association have produced disparate results. We conducted a case-control study using a purposebuilt record-linkage database for a population of 420 600 patients, resident in Tayside since May 1990. Patients (n = 207) hospitalized with a diagnostic code for ARF between 1990 and 1992 had their diagnosis validated by a renal physician. Six community controls and two hospital controls, matched for age and sex, were generated for each of these cases. Exposure to dispensed oral NSAIDs, topical NSAIDs and aspirin during the 90 days prior to the index date were investigated (recent exposure), as was exposure at any time since January 1989 (previous exposure). The most significant associations were modelled using conditional logistic regression. When community controls were used, recent exposure to NSAIDs and previous exposure to aspirin were independently associated with hospitalization for ARF, with adjusted odds ratios of 2.20 (1.49-3.25) and 2.19 (1.46-3.30), respectively. Only recent exposure to oral NSAIDs was associated when hospital controls were used: 1.84 (1.14-2.93). No significant interactions were present with previous chronic renal failure, other possible causes of ARF or whether the diagnosis was primary or secondary. There is an approximate doubling of the risk of hospitalization for ARF with use of oral NSAIDs.en_UK
dc.language.isoenen_UK
dc.publisherOxford University Pressen_UK
dc.relationEvans J, McGregor E, McMahon AD, McGilchrist MM, Jones MC, White G, McDevitt DG & MacDonald TM (1995) Non-steroidal anti-inflammatory drugs and hospitalization for acute renal failure. QJM, 88 (8), pp. 551-557. http://qjmed.oxfordjournals.org/content/88/8/551.abstracten_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.titleNon-steroidal anti-inflammatory drugs and hospitalization for acute renal failureen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate3000-01-01en_UK
dc.rights.embargoreason[nsaidrenal.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleQJM: An International Journal of Medicineen_UK
dc.citation.issn1460-2393en_UK
dc.citation.issn1460-2725en_UK
dc.citation.volume88en_UK
dc.citation.issue8en_UK
dc.citation.spage551en_UK
dc.citation.epage557en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.identifier.urlhttp://qjmed.oxfordjournals.org/content/88/8/551.abstracten_UK
dc.author.emailjosie.evans@stir.ac.uken_UK
dc.contributor.affiliationHealth Sciences Research - Stirling - LEGACYen_UK
dc.contributor.affiliationNinewells Hospital & Medical Schoolen_UK
dc.contributor.affiliationNinewells Hospital & Medical Schoolen_UK
dc.contributor.affiliationNinewells Hospital & Medical Schoolen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationNinewells Hospital & Medical Schoolen_UK
dc.contributor.affiliationNinewells Hospital & Medical Schoolen_UK
dc.contributor.affiliationNinewells Hospital & Medical Schoolen_UK
dc.identifier.isiWOS:A1995RP83100004en_UK
dc.identifier.wtid781269en_UK
dc.contributor.orcid0000-0001-6672-7876en_UK
dcterms.dateAccepted1995-08-31en_UK
dc.date.filedepositdate2012-09-03en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorEvans, Josie|0000-0001-6672-7876en_UK
local.rioxx.authorMcGregor, Ellon|en_UK
local.rioxx.authorMcMahon, Alex D|en_UK
local.rioxx.authorMcGilchrist, Mark M|en_UK
local.rioxx.authorJones, Martyn C|en_UK
local.rioxx.authorWhite, G|en_UK
local.rioxx.authorMcDevitt, Denis G|en_UK
local.rioxx.authorMacDonald, Thomas M|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate3000-01-01en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenamensaidrenal.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1460-2725en_UK
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