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dc.contributor.authorMcMahon, Alexen_UK
dc.contributor.authorEvans, Josieen_UK
dc.contributor.authorMacDonald, Thomas Men_UK
dc.description.abstractThe aim of the study was to evaluate the risks of hospitalisation and death due to hypersensitivity reactions associated with the NSAIDs naproxen and ibuprofen, using a record-linkage database for Tayside, Scotland (population 400,000). Cohorts of patients exposed to naproxen (n 54,038) and ibuprofen (n 79,513) were assembled. There were no deaths due to hypersensitivity. There was an increased risk of unvalidated hypersensitivity reactions during periods on-drug versus off-drug in patients exposed to naproxen and ibuprofen. However, after checking medical records, none of the three valid cases of hypersensitivity in the naproxen cohort and neither of the two in the ibuprofen cohort were judged to be due to NSAID exposure. A 'worst-case' scenario gave an adjusted rate-ratio of on-drug with naproxen versus on-drug with ibuprofen of 1.63 (0.50, 5.29). The study shows that hypersensitivity reactions associated with NSAID use are rare, and provides no evidence that the risks of hypersensitivity reactions differ between naproxen and ibuprofen.en_UK
dc.relationMcMahon A, Evans J & MacDonald TM (2001) Hypersensitivity reactions associated with exposure to naproxen and ibuprofen: A cohort study. Journal of Clinical Epidemiology, 54 (12), pp. 1271-1274.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectNonsteroidal anti-inflammatory drugs (NSAIDs)en_UK
dc.subjectCohort studyen_UK
dc.titleHypersensitivity reactions associated with exposure to naproxen and ibuprofen: A cohort studyen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[Evans_2001_Hypersensitivity_reactions.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleJournal of Clinical Epidemiologyen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationASS Management and Support Team - LEGACYen_UK
dc.contributor.affiliationHealth Sciences Research - Stirling - LEGACYen_UK
dc.contributor.affiliationNinewells Hospital & Medical Schoolen_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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