Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/8790
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dc.contributor.authorEvans, Josieen_UK
dc.contributor.authorDoney, Alex S Fen_UK
dc.contributor.authorAl Zadjali, Matloobaen_UK
dc.contributor.authorOgston, Simon Aen_UK
dc.contributor.authorPetrie, John Ren_UK
dc.contributor.authorMorris, Andrew Den_UK
dc.contributor.authorStruthers, Allan Den_UK
dc.contributor.authorWong, Aaron K Fen_UK
dc.contributor.authorLang, Chim Cen_UK
dc.date.accessioned2014-09-12T16:06:08Z-
dc.date.available2014-09-12T16:06:08Z-
dc.date.issued2010-10-01en_UK
dc.identifier.urihttp://hdl.handle.net/1893/8790-
dc.description.abstractType 2 diabetes mellitus (DM) plus chronic heart failure (CHF) is a common but lethal combination and therapeutic options are limited. Metformin is perceived as being relatively contraindicated in this context, although mounting evidence indicates that it may be beneficial. This study was carried out to investigate the use of metformin therapy for treating patients with DM and CHF in a large population-based cohort study. The Health Informatics Centre- dispensed prescribing database for the population of Tayside, Scotland (population 400,000) was linked to the Diabetes Audit and Research in Tayside Scotland (DARTS) information system. Patients with DM and incident CHF from 1994 to 2003 receiving oral hypoglycemic agents but not insulin were identified. Cox regression was used to assess differences in all-cause mortality rates between patients prescribed metformin and patients prescribed sulfonylureas with adjustment for co-morbidities and other therapies. Four hundred twenty-two study subjects (mean SD 75.4 0.5 years of age, 46.2% women) were identified: metformin monotherapy (n 68, mean age 75.5 1.1 years, 48.5% women), sulfonylurea monotherapy (n 217, mean age 76.7 0.7 years, 45.2% women), and combination (n 137, mean age, 73.4 0.7 years, 46.7% women). Fewer deaths occurred in metformin users, alone or in combination with sulfonylureas, compared to the sulfonylurea monotherapy cohort at 1 year (0.59, 95% confidence interval 0.36 to 0.96) and over long-term follow up (0.67, 95% confidence interval 0.51 to 0.88). In conclusion, this large observational data suggest that metformin may be beneficial in patients with CHF and DM. These findings need to be verified by a prospective clinical trial.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationEvans J, Doney ASF, Al Zadjali M, Ogston SA, Petrie JR, Morris AD, Struthers AD, Wong AKF & Lang CC (2010) Effect of Metformin on Mortality in Patients With Heart Failure and Type 2 Diabetes Mellitus. American Journal of Cardiology, 106 (7), pp. 1006-1010. https://doi.org/10.1016/j.amjcard.2010.05.031en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.titleEffect of Metformin on Mortality in Patients With Heart Failure and Type 2 Diabetes Mellitusen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-02en_UK
dc.rights.embargoreason[Evans_2010_Effect_of_Metformin.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1016/j.amjcard.2010.05.031en_UK
dc.citation.jtitleAmerican Journal of Cardiologyen_UK
dc.citation.issn0002-9149en_UK
dc.citation.volume106en_UK
dc.citation.issue7en_UK
dc.citation.spage1006en_UK
dc.citation.epage1010en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailjosie.evans@stir.ac.uken_UK
dc.contributor.affiliationHealth Sciences Research - Stirling - LEGACYen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.identifier.isiWOS:000282921300017en_UK
dc.identifier.scopusid2-s2.0-77956971910en_UK
dc.identifier.wtid781510en_UK
dc.contributor.orcid0000-0001-6672-7876en_UK
dcterms.dateAccepted2010-10-01en_UK
dc.date.filedepositdate2012-09-03en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorEvans, Josie|0000-0001-6672-7876en_UK
local.rioxx.authorDoney, Alex S F|en_UK
local.rioxx.authorAl Zadjali, Matlooba|en_UK
local.rioxx.authorOgston, Simon A|en_UK
local.rioxx.authorPetrie, John R|en_UK
local.rioxx.authorMorris, Andrew D|en_UK
local.rioxx.authorStruthers, Allan D|en_UK
local.rioxx.authorWong, Aaron K F|en_UK
local.rioxx.authorLang, Chim C|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2999-12-02en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameEvans_2010_Effect_of_Metformin.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0002-9149en_UK
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