Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/8789
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dc.contributor.authorIrvine, Lindaen_UK
dc.contributor.authorFlynn, Robert W Ven_UK
dc.contributor.authorLibby, Gillianen_UK
dc.contributor.authorCrombie, Iain Ken_UK
dc.contributor.authorEvans, Josieen_UK
dc.date.accessioned2016-12-21T22:09:30Z-
dc.date.available2016-12-21T22:09:30Z-
dc.date.issued2010-07-01en_UK
dc.identifier.urihttp://hdl.handle.net/1893/8789-
dc.description.abstractBackground: For many regularly used drugs, evidence for safe use in pregnancy has not been established. Despite this, international studies have identified high levels of drug prescribing among pregnant women. Objective: To investigate the patterns of prescribing of drugs to women who gave birth in Tayside, Scotland, in 2007. Methods: Scottish maternity records were linked to dispensed prescribing data for all women who gave birth in Tayside in 2007. Drugs prescribed were coded according to the US FDA classification for risks of drugs in pregnancy. Patterns of prescribing were investigated during the 3 trimesters of pregnancy and the 3 months prior to conception. Results: Prescribing in pregnancy was common, with 21 093 prescriptions dispensed to 3356 (85.2%) of the 3937 women. The most frequently prescribed drugs were antacids, antibacterials, oral iron, folic acid preparations and analgesics. Category A drugs (positive evidence of safety in pregnancy) and Category B drugs (some evidence of safety in pregnancy) accounted for 19.6% and 26.9% of all prescriptions dispensed, respectively. Prescribing of Category X drugs (evidence of risk to the fetus; use contraindicated in women who are or may become pregnant) during pregnancy was rare, with 112 prescriptions dispensed to 68 women (1.7%). Most of these were oral contraceptives or sex hormones. Prescribing of Category X drugs fell markedly during the first trimester and remained very low thereafter. Category D drugs (evidence of risk to the fetus but benefits of therapy may outweigh the potential risk) [432] were dispensed to 166 women (4.2%) during pregnancy. The most commonly prescribed Category D drugs were anxiolytics, nicotine replacement therapy and antiepileptic drugs. The frequency of prescribing of Category D drugs reduced in the third trimester. Prescribing of Category C drugs (insufficient evidence to know whether they are harmful) was common. Thirty percent of women received a total of 3641 Category C prescriptions, which accounted for 17.3% of all prescriptions issued during pregnancy. Prescribing of Category C drugs showed only a very modest decline during pregnancy. No FDA code was available for 4035 prescriptions issued (87 different items), the majority of which were for antacids and preparations for indigestion. More than 40% of women received such medications. Conclusions: Prescribing of drugs during pregnancy was very common, but the levels of prescribing of drugs that are known to be harmful were low. Much of the prescribing was for drugs related to the pregnancy. While this study provides some evidence that primary-care prescribers in Tayside are prescribing potentially harmful drugs appropriately and with caution during pregnancy, safety data during pregnancy are unavailable for many drugs that are commonly prescribed.en_UK
dc.language.isoenen_UK
dc.publisherAdis for International Society of Pharmacovigilanceen_UK
dc.relationIrvine L, Flynn RWV, Libby G, Crombie IK & Evans J (2010) Drugs Dispensed in Primary Care During Pregnancy A Record-Linkage Analysis in Tayside, Scotland. Drug Safety, 33 (7), pp. 593-604. https://doi.org/10.2165/11532330-000000000-00000en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.titleDrugs Dispensed in Primary Care During Pregnancy A Record-Linkage Analysis in Tayside, Scotlanden_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-02en_UK
dc.rights.embargoreason[Evans_2010_Drugs_Dispensed_in_Primary_Care.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.2165/11532330-000000000-00000en_UK
dc.identifier.pmid20553060en_UK
dc.citation.jtitleDrug Safetyen_UK
dc.citation.issn1179-1942en_UK
dc.citation.issn0114-5916en_UK
dc.citation.volume33en_UK
dc.citation.issue7en_UK
dc.citation.spage593en_UK
dc.citation.epage604en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailjosie.evans@stir.ac.uken_UK
dc.contributor.affiliationNHS Lothianen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationHealth Sciences Research - Stirling - LEGACYen_UK
dc.identifier.isiWOS:000280086700007en_UK
dc.identifier.scopusid2-s2.0-77953594954en_UK
dc.identifier.wtid781536en_UK
dc.contributor.orcid0000-0001-6672-7876en_UK
dcterms.dateAccepted2010-07-01en_UK
dc.date.filedepositdate2012-09-03en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorIrvine, Linda|en_UK
local.rioxx.authorFlynn, Robert W V|en_UK
local.rioxx.authorLibby, Gillian|en_UK
local.rioxx.authorCrombie, Iain K|en_UK
local.rioxx.authorEvans, Josie|0000-0001-6672-7876en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2999-12-02en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameEvans_2010_Drugs_Dispensed_in_Primary_Care.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0114-5916en_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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