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Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Mortality in people diagnosed with type 2 diabetes at an older age: a systematic review
Author(s): Barnett, Karen N
McMurdo, Marion E T
Ogston, Simon A
Morris, Andrew D
Evans, Josie
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Keywords: Type 2 diabetes
Older people
Issue Date: Sep-2006
Date Deposited: 3-Sep-2012
Citation: Barnett KN, McMurdo MET, Ogston SA, Morris AD & Evans J (2006) Mortality in people diagnosed with type 2 diabetes at an older age: a systematic review. Age and Ageing, 35 (5), pp. 463-468.
Abstract: Objectives: to review all published observational studies reporting on all-cause mortality in patients with type 2 diabetes to determine the degree of increased mortality when diagnosed at an older age. Design: systematic literature search. Setting: the review included studies carried out in populations from Germany, United Kingdom, United States, Japan, Italy, Western Australia, Netherlands and Sweden. Measurements: Medline, CINAHL, EMBASE, National Research Register and Cochrane Reviews were systematically searched from 1975 to 2004. We identified observational studies that reported overall mortality for people diagnosed with type 2 diabetes when they were over the age of 60, compared with a non-diabetic population. Outcome measures were expressed as risk ratios or relative risks. Results: among 14 eligible studies, one study reported reduced mortality for patients diagnosed with type 2 diabetes over the age of 60, whereas another found virtually no increased risk of mortality. However, 7 of the 14 studies reported increased mortality in all patients diagnosed when older, and 5 studies for certain subgroups only. A meta-analysis showed the combined relative risks (with 95% CI) of increased mortality for men diagnosed between the ages of 60 and 70 to be 1.38 (1.08- 1.76) and 1.13 (0.88-1.45) for men diagnosed aged 70 years or older. A similar pattern was found for the same age groups for women, with combined relative risks of 1.40 (1.10-1.79) and 1.19 (0.93-1.52) respectively. Conclusion: increased mortality associated with a diagnosis of type 2 diabetes at an older age is lower than that reported for the general older diabetic population.
DOI Link: 10.1093/ageing/afl019
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