Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/8786
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dc.contributor.authorEmslie-Smith, Alistair M-
dc.contributor.authorBoyle, Douglas I R-
dc.contributor.authorEvans, Josie-
dc.contributor.authorSullivan, Frank M-
dc.contributor.authorMorris, Andrew D-
dc.date.accessioned2014-09-12T16:21:46Z-
dc.date.issued2001-06-
dc.identifier.urihttp://hdl.handle.net/1893/8786-
dc.description.abstractAims: To define the number of people in Tayside, Scotland (population 349 303) with Type 2 diabetes who use metformin, the incidence of contraindications to its continued use in these people and the proportion that discontinued metformin treatment following the development of a contraindication. Methods: Retrospective cohort study of the incidence of contraindications to metformin in all patients with Type 2 diabetes using metformin from January 1993 to June 1995. The contraindications of acute myocardial infarction, cardiac failure, renal impairment and chronic liver disease were identified by: the regional diabetes information system, biochemistry database and hospital admissions database and a database of all encashed community prescriptions. Results: One thousand eight hundred and forty seven subjects (26.3% of those with Type 2 diabetes) redeemed prescriptions for metformin. Of these, 3.5% were admitted with an acute myocardial infarction (71 episodes); 4.2% were admitted with cardiac failure (114 episodes); 21.0% received metformin and loop diuretics for cardiac failure concurrently; 4.8% developed renal impairment; and 2.8% developed chronic liver disease. The development of contraindications rarely resulted in discontinuation of metformin, for example only 17.5% and 25% stopped metformin after admission with acute myocardial infarction and development of renal impairment, respectively. In total, 24.5% of subjects receiving metformin, 6.4% of all people with Type 2 diabetes, had contraindications to its use. There was one episode of lactic acidosis in 4600 patient years. Conclusions: This population-based study shows that 24.5% of patients prescribed metformin have contraindications to its use. Development of contraindications rarely results in discontinuation of metformin therapy. Despite this, lactic acidosis remains rare.en_UK
dc.language.isoen-
dc.publisherWiley-Blackwell for Diabetes UK-
dc.relationEmslie-Smith AM, Boyle DIR, Evans J, Sullivan FM & Morris AD (2001) Contraindications to metformin therapy in patients with Type 2 diabetes - a population-based study of adherence to prescribing guidelines, Diabetic Medicine, 18 (6), pp. 483-488.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectContraindicationsen_UK
dc.subjectDiscontinueen_UK
dc.subjectLactic acidosisen_UK
dc.subjectMetforminen_UK
dc.subjectType 2 diabetes mellitusen_UK
dc.titleContraindications to metformin therapy in patients with Type 2 diabetes - a population-based study of adherence to prescribing guidelinesen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31T00:00:00Z-
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.identifier.doihttp://dx.doi.org/10.1046/j.1464-5491.2001.00509.x-
dc.citation.jtitleDiabetic Medicine-
dc.citation.issn0742-3071-
dc.citation.volume18-
dc.citation.issue6-
dc.citation.spage483-
dc.citation.epage488-
dc.citation.publicationstatusPublished-
dc.citation.peerreviewedRefereed-
dc.type.statusPublisher version (final published refereed version)-
dc.author.emailjosie.evans@stir.ac.uk-
dc.citation.date20/12/2001-
dc.contributor.affiliationTayside Centre for General Practice-
dc.contributor.affiliationUniversity of Dundee-
dc.contributor.affiliationHS Research - Stirling-
dc.contributor.affiliationUniversity of Dundee-
dc.contributor.affiliationUniversity of Dundee-
dc.rights.embargoterms2999-12-31-
dc.rights.embargoliftdate2999-12-31-
dc.identifier.isi000170084800009-
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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