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http://hdl.handle.net/1893/7632
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DC Field | Value | Language |
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dc.contributor.author | Breen, Leigh | en_UK |
dc.contributor.author | Philp, Andrew | en_UK |
dc.contributor.author | Shaw, Christopher S | en_UK |
dc.contributor.author | Jeukendrup, Asker E | en_UK |
dc.contributor.author | Baar, Keith | en_UK |
dc.contributor.author | Tipton, Kevin | en_UK |
dc.date.accessioned | 2016-08-26T01:20:34Z | - |
dc.date.available | 2016-08-26T01:20:34Z | - |
dc.date.issued | 2011-06-20 | en_UK |
dc.identifier.uri | http://hdl.handle.net/1893/7632 | - |
dc.description.abstract | Purpose: To investigate the mechanisms underpinning modifications in glucose homeostasis and insulin sensitivity 24 h after a bout of resistance exercise (RE) with or without protein ingestion. Methods: Twenty-four healthy males were assigned to a control (CON; n = 8), exercise (EX; n = 8) or exercise plus protein condition (EX+PRO; n = 8). Muscle biopsy and blood samples were obtained at rest for all groups and immediately post-RE (75% 1RM, 8×10 repetitions of leg-press and extension exercise) for EX and EX+PRO only. At 24 h post-RE (or post-resting biopsy for CON), a further muscle biopsy was obtained. Participants then consumed an oral glucose load (OGTT) containing 2 g of [U-13C] glucose during an infusion of 6, 6-[2H2] glucose. Blood samples were obtained every 10 min for 2 h to determine glucose kinetics. EX+PRO ingested an additional 25 g of intact whey protein with the OGTT. A final biopsy sample was obtained at the end of the OGTT. Results: Fasted plasma glucose and insulin were similar for all groups and were not different immediately post- and 24 h post-RE. Following RE, muscle glycogen was 26±8 and 19±6% lower in EX and EX+PRO, respectively. During OGTT, plasma glucose AUC was lower for EX and EX+PRO (75.1±2.7 and 75.3±2.8 mmol·L-1:120 min, respectively) compared with CON (90.6±4.1 mmol·L-1:120 min). Plasma insulin response was 13±2 and 21±4% lower for EX and CON, respectively, compared with EX+PRO. Glucose disappearance from the circulation was ~12% greater in EX and EX+PRO compared with CON. Basal 24 h post-RE and insulin-stimulated PAS-AS160/TBC1D4 phosphorylation was greater for EX and EX+PRO. Conclusions: Prior RE improves glycemic control and insulin sensitivity through an increase in the rate at which glucose is disposed from the circulation. However, co-ingesting protein during a high-glucose load does not augment this response at 24 h post-exercise in healthy, insulin-sensitive individuals. | en_UK |
dc.language.iso | en | en_UK |
dc.publisher | Public Library of Science | en_UK |
dc.relation | Breen L, Philp A, Shaw CS, Jeukendrup AE, Baar K & Tipton K (2011) Beneficial Effects of Resistance Exercise on Glycemic Control Are Not Further Improved by Protein Ingestion. PLoS ONE, 6 (6), p. e20613. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0020613; https://doi.org/10.1371/journal.pone.0020613 | en_UK |
dc.rights | Publisher is open-access. Open access publishing allows free access to and distribution of published articles where the author retains copyright of their work by employing a Creative Commons attribution licence. Proper attribution of authorship and correct citation details should be given. Publisher’s policy available from http://www.plos.org/about/open-access/license/. | en_UK |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_UK |
dc.title | Beneficial Effects of Resistance Exercise on Glycemic Control Are Not Further Improved by Protein Ingestion | en_UK |
dc.type | Journal Article | en_UK |
dc.identifier.doi | 10.1371/journal.pone.0020613 | en_UK |
dc.citation.jtitle | PLoS ONE | en_UK |
dc.citation.issn | 1932-6203 | en_UK |
dc.citation.volume | 6 | en_UK |
dc.citation.issue | 6 | en_UK |
dc.citation.spage | e20613 | en_UK |
dc.citation.publicationstatus | Published | en_UK |
dc.citation.peerreviewed | Refereed | en_UK |
dc.type.status | VoR - Version of Record | en_UK |
dc.identifier.url | http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0020613 | en_UK |
dc.author.email | k.d.tipton@stir.ac.uk | en_UK |
dc.contributor.affiliation | University of Birmingham | en_UK |
dc.contributor.affiliation | University of California | en_UK |
dc.contributor.affiliation | University of Birmingham | en_UK |
dc.contributor.affiliation | University of Birmingham | en_UK |
dc.contributor.affiliation | University of California, Davis | en_UK |
dc.contributor.affiliation | Sport | en_UK |
dc.identifier.isi | WOS:000291983800007 | en_UK |
dc.identifier.scopusid | 2-s2.0-79959316895 | en_UK |
dc.identifier.wtid | 778975 | en_UK |
dc.contributor.orcid | 0000-0002-6545-8122 | en_UK |
dc.date.accepted | 2011-05-05 | en_UK |
dcterms.dateAccepted | 2011-05-05 | en_UK |
dc.date.filedepositdate | 2012-08-24 | en_UK |
rioxxterms.type | Journal Article/Review | en_UK |
rioxxterms.version | VoR | en_UK |
local.rioxx.author | Breen, Leigh| | en_UK |
local.rioxx.author | Philp, Andrew| | en_UK |
local.rioxx.author | Shaw, Christopher S| | en_UK |
local.rioxx.author | Jeukendrup, Asker E| | en_UK |
local.rioxx.author | Baar, Keith| | en_UK |
local.rioxx.author | Tipton, Kevin|0000-0002-6545-8122 | en_UK |
local.rioxx.project | Internal Project|University of Stirling|https://isni.org/isni/0000000122484331 | en_UK |
local.rioxx.freetoreaddate | 2012-08-24 | en_UK |
local.rioxx.licence | http://creativecommons.org/licenses/by/4.0/|2012-08-24| | en_UK |
local.rioxx.filename | journal.pone.0020613.pdf | en_UK |
local.rioxx.filecount | 1 | en_UK |
Appears in Collections: | Faculty of Health Sciences and Sport Journal Articles |
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journal.pone.0020613.pdf | Fulltext - Published Version | 777.16 kB | Adobe PDF | View/Open |
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