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Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Dietary protein intake impacts human skeletal muscle protein fractional synthetic rates after endurance exercise
Author(s): Bolster, Douglas R
Pikosky, Matthew A
Gaine, P Courtney
Martin, William
Wolfe, Robert R
Tipton, Kevin
Maclean, David
Maresh, Carl M
Rodriguez, Nancy R
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Keywords: amino acids
fractional synthetic rate
Issue Date: Oct-2005
Date Deposited: 24-Aug-2012
Citation: Bolster DR, Pikosky MA, Gaine PC, Martin W, Wolfe RR, Tipton K, Maclean D, Maresh CM & Rodriguez NR (2005) Dietary protein intake impacts human skeletal muscle protein fractional synthetic rates after endurance exercise. American Journal of Physiology - Endocrinology and Metabolism, 289 (4), pp. E678-E683.;
Abstract: This investigation evaluated the physiological impact of different dietary protein intakes on skeletal muscle protein synthesis postexercise in endurance runners. Five endurance-trained, male runners participated in a randomized, crossover design diet intervention, where they consumed either a low (0.8 g/kg; LP)-, moderate (1.8 g/kg; MP)-, or high (3.6 g/kg; HP)-protein diet for 4 wk. Diets were designed to be eucaloric with carbohydrate, fat, and protein approximating 60, 30, and 10%; 55, 30, and 15%; and 40, 30, and 30% for LP, MP, and HP, respectively. Substrate oxidation was assessed via indirect calorimetry at 3 wk of the dietary interventions. Mixed-muscle protein fractional synthetic rate (FSR) was measured after an endurance run (75 min at 70% V̇o2 peak) using a primed, continuous infusion of [2H5]phenylalanine. Protein oxidation increased with increasing protein intake, with each trial being significantly different from the other (P less than 0.01). FSR after exercise was significantly greater for LP (0.083%/h) and MP (0.078%/h) than for HP (0.052%/h; P less than 0.05). There was no difference in FSR between LP and MP. This is the first investigation to establish that habitual dietary protein intake in humans modulates skeletal muscle protein synthesis after an endurance exercise bout. Future studies directed at mechanisms by which level of protein intake influences skeletal muscle turnover are needed.
DOI Link: 10.1152/ajpendo.00060.2005
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