|Appears in Collections:||Faculty of Health Sciences and Sport Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Acute response of net muscle protein balance reflects 24-h balance after exercise and amino acid ingestion|
Wolf, Steven E
Sanford, Arthur P
Wolfe, Robert R
|Keywords:||muscle protein synthesis|
muscle protein breakdown
stable isotopic tracers
|Citation:||Tipton K, Borsheim E, Wolf SE, Sanford AP & Wolfe RR (2003) Acute response of net muscle protein balance reflects 24-h balance after exercise and amino acid ingestion, American Journal of Physiology - Endocrinology and Metabolism, 284 (1), pp. E76-E89.|
|Abstract:||The purpose of this study was to determine if the acute anabolic muscle response to resistance exercise and essential amino acids (EAA) reflects the response over 24 h. Seven subjects participated in the following two 24-h studies: 1) resting (REST) and2) rest plus resistance exercise and consumption of EAA (ES). Net balance (NB) across the leg was determined for four amino acids. [13C6]phenylalanine was infused to determine mixed muscle fractional synthetic rate (FSR). Twenty-four-hour FSR was significantly greater for ES than for REST (P = 0.003). Exchange of phenylalanine across the leg was -194 ± 74 (SE) mg for ES and -371 ± 88 mg for REST (P = 0.07) over 24 h and 229 ± 42 mg (ES) and 28 ± 15 mg (REST; P less than 0.01) over 3 h corresponding to exercise and EAA consumption for ES. The difference in phenylalanine exchange between REST and ES was not different for measurements over 24 and 3 h. Increases in NB during ES were primarily the result of increases in protein synthesis. Results for other amino acids were similar. The acute anabolic response of muscle to EAA intake and exercise is additive to the response at rest and thus reflects the 24-h response.|
|Rights:||The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.|
|E76.full.pdf||362.28 kB||Adobe PDF||Under Permanent Embargo Request a copy|
Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependent on the depositor still being contactable at their original email address.
This item is protected by original copyright
Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
If you believe that any material held in STORRE infringes copyright, please contact email@example.com providing details and we will remove the Work from public display in STORRE and investigate your claim.