Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/7596
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dc.contributor.authorCosgrove, Cormac-
dc.contributor.authorGalloway, S D-
dc.contributor.authorNeal, Craig M-
dc.contributor.authorHunter, Angus-
dc.contributor.authorMcFarlin, Brian K-
dc.contributor.authorSpielmann, Guillaume-
dc.contributor.authorSimpson, Richard J-
dc.date.accessioned2016-10-20T01:33:43Z-
dc.date.issued2012-08-
dc.identifier.urihttp://hdl.handle.net/1893/7596-
dc.description.abstractAthletes appear to be at a greater risk of illness while undertaking arduous training regimens in preparation for endurance events. As infection susceptibility has been linked with increased proportions of differentiated and senescent T cells in the periphery, changes in the proportions of these cell types due to long-term high-volume exercise training could have important implications for athlete infection risk. This study examined the effects of 6-month training preparation for an Ironman triathlon on the proportions of naïve, memory and senescent T cells in resting blood. Ten club-level triathletes (9 males; 1 female: 43 ± 3 years) were sampled at 27 (December), 21 (January), 15 (March), 9 (May) and 3 (June) weeks before an Ironman Triathlon. An additional sample was collected 2-week post-competition (August). Four-colour flow cytometry was used for the phenotypic analysis of CD4+ and CD8+ blood T cells. Proportions of differentiated (KLRG1+/CD57−) CD8+ T cells and "transitional" (CD45RA+/CD45RO+) CD4+ and CD8+ T cells increased with training, as the values in June were elevated 37, 142 and 116%, respectively, from those observed in December. Proportions of senescent (KLRG1+/CD57+) CD4+ or CD8+ T cells did not change during the training phase. Two weeks post-race, proportions of differentiated CD8+ T cells had returned to baseline values, while the proportions of senescent CD4+ T cells increased 192% alongside a 31% reduction in naïve (CD45RA+/CD45RO−) cells. In conclusion, increases in differentiated and "transitional" T cells due to arduous exercise training could compromise host protection to novel pathogens and increase athlete infection risk, although whether or not the composition of naïve and differentiated T cells in blood can serve as prognostic biomarkers in athletes remains to be established.en_UK
dc.language.isoen-
dc.publisherSpringer-
dc.relationCosgrove C, Galloway SD, Neal CM, Hunter A, McFarlin BK, Spielmann G & Simpson RJ (2012) The impact of 6-month training preparation for an Ironman triathlon on the proportions of naive, memory and senescent T cells in resting blood, European Journal of Applied Physiology, 112 (8), pp. 2989-2998.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectKLRG1en_UK
dc.subjectExercise immunologyen_UK
dc.subjectEndurance trainingen_UK
dc.subjectFlow cytometryen_UK
dc.titleThe impact of 6-month training preparation for an Ironman triathlon on the proportions of naive, memory and senescent T cells in resting blooden_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31T00:00:00Z-
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.identifier.doihttp://dx.doi.org/10.1007/s00421-011-2273-9-
dc.citation.jtitleEuropean Journal of Applied Physiology-
dc.citation.issn1439-6319-
dc.citation.volume112-
dc.citation.issue8-
dc.citation.spage2989-
dc.citation.epage2998-
dc.citation.publicationstatusPublished-
dc.citation.peerreviewedRefereed-
dc.type.statusPublisher version (final published refereed version)-
dc.identifier.urlhttp://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-83255165477&md5=f265bffda2911a51185478f030ef1ce3-
dc.author.emails.d.r.galloway@stir.ac.uk-
dc.citation.date15/12/2011-
dc.contributor.affiliationEdinburgh Napier University-
dc.contributor.affiliationSport-
dc.contributor.affiliationUniversity of Stirling-
dc.contributor.affiliationSport-
dc.contributor.affiliationUniversity of Houston-
dc.contributor.affiliationUniversity of Houston-
dc.contributor.affiliationEdinburgh Napier University-
dc.rights.embargoterms2999-12-31-
dc.rights.embargoliftdate2999-12-31-
dc.identifier.isi000306340700018-
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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