Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/7553
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dc.contributor.authorTipton, Kevin-
dc.contributor.authorRasmussen, Blake B-
dc.contributor.authorMiller, Sharon L-
dc.contributor.authorWolf, Steven E-
dc.contributor.authorOwens-Stovall, Sharla K-
dc.contributor.authorPetrini, Bart E-
dc.contributor.authorWolfe, Robert R-
dc.date.accessioned2016-09-11T20:37:22Z-
dc.date.issued2001-08-
dc.identifier.urihttp://hdl.handle.net/1893/7553-
dc.description.abstractThe present study was designed to determine whether consumption of an oral essential amino acid-carbohydrate supplement (EAC) before exercise results in a greater anabolic response than supplementation after resistance exercise. Six healthy human subjects participated in two trials in random order, PRE (EAC consumed immediately before exercise), and POST (EAC consumed immediately after exercise). A primed, continuous infusion ofl-[ring-2H5]phenylalanine, femoral arteriovenous catheterization, and muscle biopsies from the vastus lateralis were used to determine phenylalanine concentrations, enrichments, and net uptake across the leg. Blood and muscle phenylalanine concentrations were increased by ∼130% after drink consumption in both trials. Amino acid delivery to the leg was increased during exercise and remained elevated for the 2 h after exercise in both trials. Delivery of amino acids (amino acid concentration times blood flow) was significantly greater in PRE than in POST during the exercise bout and in the 1st h after exercise (P less than 0.05). Total net phenylalanine uptake across the leg was greater (P = 0.0002) during PRE (209 ± 42 mg) than during POST (81 ± 19). Phenylalanine disappearance rate, an indicator of muscle protein synthesis from blood amino acids, increased after EAC consumption in both trials. These results indicate that the response of net muscle protein synthesis to consumption of an EAC solution immediately before resistance exercise is greater than that when the solution is consumed after exercise, primarily because of an increase in muscle protein synthesis as a result of increased delivery of amino acids to the leg.en_UK
dc.language.isoen-
dc.publisherThe American Physiological Society-
dc.relationTipton K, Rasmussen BB, Miller SL, Wolf SE, Owens-Stovall SK, Petrini BE & Wolfe RR (2001) Timing of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exercise, American Journal of Physiology - Endocrinology and Metabolism, 281 (2), pp. E197-E206.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectmuscle protein synthesisen_UK
dc.subjectmuscle protein breakdownen_UK
dc.subjectstable isotopesen_UK
dc.subjectsupplementationen_UK
dc.titleTiming of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exerciseen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31T00:00:00Z-
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.citation.jtitleAmerican Journal of Physiology - Endocrinology and Metabolism-
dc.citation.issn0193-1849-
dc.citation.volume281-
dc.citation.issue2-
dc.citation.spageE197-
dc.citation.epageE206-
dc.citation.publicationstatusPublished-
dc.citation.peerreviewedRefereed-
dc.type.statusPublisher version (final published refereed version)-
dc.identifier.urlhttp://ajpendo.physiology.org/content/281/2/E197.abstract-
dc.author.emailk.d.tipton@stir.ac.uk-
dc.contributor.affiliationSport-
dc.contributor.affiliationUniversity of Texas Medical Branch-
dc.contributor.affiliationUniversity of Texas Medical Branch-
dc.contributor.affiliationUniversity of Texas Medical Branch-
dc.contributor.affiliationUniversity of Texas Medical Branch-
dc.contributor.affiliationUniversity of Texas Medical Branch-
dc.contributor.affiliationUniversity of Texas-
dc.rights.embargoterms2999-12-31-
dc.rights.embargoliftdate2999-12-31-
dc.identifier.isi000170302900001-
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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