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Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/7512
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dc.contributor.authorEvans, Josieen_UK
dc.contributor.authorDonnelly, Louise Aen_UK
dc.contributor.authorEmslie-Smith, Alistair Men_UK
dc.contributor.authorAlessi, Dario Ren_UK
dc.contributor.authorMorris, Andrew Den_UK
dc.date.accessioned2014-09-12T07:34:27Z-
dc.date.available2014-09-12T07:34:27Z-
dc.date.issued2005-06-04en_UK
dc.identifier.urihttp://hdl.handle.net/1893/7512-
dc.description.abstractMetformin, widely given to patients with type 2 diabetes, works by targeting the enzyme AMPK (AMP activated protein kinase), which induces muscles to take up glucose from the blood. A recent breakthrough has found the upstream regulator of AMPK to be a protein kinase known as LKB1.1 2 LKB1 is a well recognised tumour suppressor. Activation of AMPK by metformin and exercise requires LKB1, and this would also explain why exercise is beneficial in the primary and secondary prevention of certain cancers.3 We hypothesise that metformin use in patients with type 2 diabetes may reduce their risk of cancer.en_UK
dc.language.isoenen_UK
dc.publisherBMJ Publishing Groupen_UK
dc.relationEvans J, Donnelly LA, Emslie-Smith AM, Alessi DR & Morris AD (2005) Metformin and reduced risk of cancer in diabetic patients. BMJ, 330 (7503), pp. 1304-1305. https://doi.org/10.1136/bmj.38415.708634.F7en_UK
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode. Published in BMJ by BMJ Publishing Group Ltd. The published article can be accessed at: http://www.bmj.com/content/330/7503/1304en_UK
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en_UK
dc.subjectDiabetesen_UK
dc.subjectMetabolic disordersen_UK
dc.subjectEpidemiologic studiesen_UK
dc.subjectHealth educationen_UK
dc.subjectHealth promotionen_UK
dc.subjectHypertensionen_UK
dc.titleMetformin and reduced risk of cancer in diabetic patientsen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1136/bmj.38415.708634.F7en_UK
dc.citation.jtitleBMJen_UK
dc.citation.issn1756-1833en_UK
dc.citation.issn0959-8138en_UK
dc.citation.volume330en_UK
dc.citation.issue7503en_UK
dc.citation.spage1304en_UK
dc.citation.epage1305en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailjosie.evans@stir.ac.uken_UK
dc.citation.date22/04/2005en_UK
dc.contributor.affiliationHealth Sciences Research - Stirling - LEGACYen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationTayside Centre for General Practiceen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.identifier.isiWOS:000229655700023en_UK
dc.identifier.wtid781386en_UK
dc.contributor.orcid0000-0001-6672-7876en_UK
dcterms.dateAccepted2005-04-22en_UK
dc.date.filedepositdate2012-08-20en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorEvans, Josie|0000-0001-6672-7876en_UK
local.rioxx.authorDonnelly, Louise A|en_UK
local.rioxx.authorEmslie-Smith, Alistair M|en_UK
local.rioxx.authorAlessi, Dario R|en_UK
local.rioxx.authorMorris, Andrew D|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2012-08-20en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by-nc/3.0/|2012-08-20|en_UK
local.rioxx.filenameEvans_2005_Metformin_and_reduced_risk_of_cancer.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0959-8138en_UK
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