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Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Tolerability of topical NSAIDs in the elderly - Do they really convey a safety advantage?
Author(s): Evans, Josie
MacDonald, Thomas M
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Issue Date: Aug-1996
Date Deposited: 3-Aug-2012
Citation: Evans J & MacDonald TM (1996) Tolerability of topical NSAIDs in the elderly - Do they really convey a safety advantage?. Drugs and Aging, 9 (2), pp. 101-108.
Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) are very widely prescribed but they have a poor safety profile, with a range of potential adverse effects. NSAIDs that are used in topical formulation have been developed in the last fifteen years and their use is increasing. The purpose is to achieve a high local concentration of the active ingredient at the affected site, with as low a plasma concentration as possible to minimise possible systemic side-effects. This paper reviews the evidence available regarding the safety of topical NSAIDs, with particular reference to gastrointestinal and renal toxicity which have recently been highlighted in the medical press. The effects on the elderly are also discussed. The authors conclude that more formal epidemiological evaluation of the safety of topical NSAIDs is required in the post-marketing situation.
DOI Link: 10.2165/00002512-199609020-00005
Rights: This is a non-final version of an article published in final form in Drugs & Aging, 9(2):101-108, August 1996.

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