Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/7162
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dc.contributor.authorEvans, Josieen_UK
dc.contributor.authorMcMahon, Alex Den_UK
dc.contributor.authorMcGilchrist, Mark Men_UK
dc.contributor.authorWhite, Gen_UK
dc.contributor.authorMurray, Frank Een_UK
dc.contributor.authorMcDevitt, Denis Gen_UK
dc.contributor.authorMacDonald, Thomas Men_UK
dc.date.accessioned2014-09-12T10:07:54Z-
dc.date.available2014-09-12T10:07:54Z-
dc.date.issued1995-07-01en_UK
dc.identifier.urihttp://hdl.handle.net/1893/7162-
dc.description.abstractObjective: To evaluate the relation between topically applied non-steroidal anti-inflammatory drugs and upper gastrointestinal bleeding and perforation. Design: A case-control study with 1103 patients admitted to hospital for upper gastrointestinal bleeding or perforation between January 1990 and December 1992 (cases). Two different control groups were used, with six community controls and with two hospital controls for each case. Previous exposure to topical and oral non-steroidal anti-inflammatory drugs and ulcer healing drugs was assessed. Study population: The population of 319465 people who were resident in Tayside and were registered with a Tayside general practitioner between January 1989 and October 1994. A record linkage database containing all data on hospital events and dispensed drugs between 1989 and 1992 was used for this population. Main outcome measures: Unadjusted and adjusted odds ratios of exposure in those admitted to hospital compared with controls. Results: Significant unadjusted associations were detected between all three classes of drug and upper gastrointestinal complications. The significant association detected for topical non-steroidal anti-inflammatory drugs was no longer evident in analyses which adjusted for the confounding effect of concomitant exposure to oral anti-inflammatories and ulcer healing drugs (odds ratio=1.45; 95% confidence interval 0.84 to 2.50 with community controls; 1.06; 0.60 to 1.88 with hospital controls). Conclusion: In this study topical non-steroidal anti-inflammatory drugs were not significantly associated with upper gastrointestinal bleeding and perforation after adjustment for the confounding effects of concomitant use of oral anti-inflammatories and ulcer healing drugs.en_UK
dc.language.isoenen_UK
dc.publisherBritish Medical Associationen_UK
dc.relationEvans J, McMahon AD, McGilchrist MM, White G, Murray FE, McDevitt DG & MacDonald TM (1995) Topical non-steroidal anti-inflammatory drugs and admission to hospital for upper gastrointestinal bleeding and perforation: a record linkage case-control study. BMJ, 311 (6996), pp. 22-26. http://www.bmj.com/content/311/6996/22; https://doi.org/10.1136/bmj.311.6996.22en_UK
dc.rightsPublisher policy allows this work to be made available in this repository. Published in British Medical Journal by British Medical Association copyright 1995. http://www.bmj.com/content/311/6996/22en_UK
dc.titleTopical non-steroidal anti-inflammatory drugs and admission to hospital for upper gastrointestinal bleeding and perforation: a record linkage case-control studyen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1136/bmj.311.6996.22en_UK
dc.citation.jtitleBMJen_UK
dc.citation.issn1756-1833en_UK
dc.citation.issn0959-8138en_UK
dc.citation.volume311en_UK
dc.citation.issue6996en_UK
dc.citation.spage22en_UK
dc.citation.epage26en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.identifier.urlhttp://www.bmj.com/content/311/6996/22en_UK
dc.author.emailjosie.evans@stir.ac.uken_UK
dc.contributor.affiliationHealth Sciences Research - Stirling - LEGACYen_UK
dc.contributor.affiliationNinewells Hospital & Medical Schoolen_UK
dc.contributor.affiliationNinewells Hospital & Medical Schoolen_UK
dc.contributor.affiliationNinewells Hospital & Medical Schoolen_UK
dc.contributor.affiliationNinewells Hospital & Medical Schoolen_UK
dc.contributor.affiliationNinewells Hospital & Medical Schoolen_UK
dc.contributor.affiliationNinewells Hospital & Medical Schoolen_UK
dc.identifier.isiWOS:A1995RG97500020en_UK
dc.identifier.wtid781029en_UK
dc.contributor.orcid0000-0001-6672-7876en_UK
dcterms.dateAccepted1995-07-01en_UK
dc.date.filedepositdate2012-08-01en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorEvans, Josie|0000-0001-6672-7876en_UK
local.rioxx.authorMcMahon, Alex D|en_UK
local.rioxx.authorMcGilchrist, Mark M|en_UK
local.rioxx.authorWhite, G|en_UK
local.rioxx.authorMurray, Frank E|en_UK
local.rioxx.authorMcDevitt, Denis G|en_UK
local.rioxx.authorMacDonald, Thomas M|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2012-08-01en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/all-rights-reserved|2012-08-01|en_UK
local.rioxx.filenameTOPBLEED.pdfen_UK
local.rioxx.filecount2en_UK
local.rioxx.source0959-8138en_UK
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