Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/37786
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dc.contributor.authorMcCulloch, Peteren_UK
dc.contributor.authorShaw, Aprilen_UK
dc.contributor.authorGilchrist, Gailen_UK
dc.contributor.authorMatheson, Catrionaen_UK
dc.contributor.authorMaxwell, Margareten_UK
dc.contributor.authorNeale, Joanneen_UK
dc.contributor.authorMyring, Garethen_UK
dc.contributor.authorMcLeod, Hughen_UK
dc.contributor.authorHickman, Matten_UK
dc.contributor.authorVickerman, Peteren_UK
dc.contributor.authorMunro, Alisonen_UK
dc.contributor.authorMacGillivray, Steveen_UK
dc.date.accessioned2026-01-24T01:18:22Z-
dc.date.available2026-01-24T01:18:22Z-
dc.date.issued2025-12en_UK
dc.identifier.urihttp://hdl.handle.net/1893/37786-
dc.description.abstractBackground The barriers and facilitators to engagement with Opiate Substitute Treatment and Needle and Syringe Provision need to be better understood to develop interventions to attract people into services. Objective(s) We conducted a multi-method realist evaluation to generate an in-depth theory of the factors that influence the optimal provision of services in terms of access, engagement, retention and successful exit. Design Multi-method involving an online survey of United Kingdom drug and alcohol service commissioning leads and a meta-synthesis of qualitative literature (phase 1) to facilitate the development of an initial theory of optimal provision; and, in phase 2, a realist evaluation to test and refine the initial theory, involving in-depth interviews across three United Kingdom sites, with service commissioners, managers, staff and service users. We used routine treatment and staffing data to estimate the additional staff costs of implementing optimal service provision within one context of our refined theory. Results Findings indicated that optimal provision could be understood with reference to five main contexts [(1) agency and empowerment, (2) self-esteem and respect, (3) knowledge and communication, (4) goals, needs and preferences and (5) resources and demands]. The analysis suggested that optimal provision could be facilitated via specific mechanisms of action, operating at the ‘Systems level’ (policy, legislation and funding) and ‘Service level’ (delivery of services, service pathways, staff roles and responsibilities and organisational culture). Our analysis also identified the potential importance of independent ‘mediating mechanisms’ (e.g. confidence, trust and self-efficacy) which can operate to increase the likelihood of successful service outcomes. A costing analysis estimated the costs associated with a smaller caseload for shared care workers and the implementation of a salary increment scheme at one of the study sites. Limitations The survey sample size limited generalisability. There was a limited number of United Kingdom studies within the meta-synthesis. The findings of the realist evaluation highlight that provision was not optimised in the observed sites, limiting examples of best practice. However, the conceptual theory of optimal provision can direct future research to facilitate the development and implementation of optimal policy and practice. Conclusions We have provided a rich understanding of the contexts, mechanisms and actions by which optimal delivery of Opiate Substitute Treatment and Needle and Syringe Provision services may increase the likelihood of successful service provision. A multiagency approach applying various mechanisms within the various contexts of optimal provision may need to be implemented to optimise the provision.en_UK
dc.language.isoenen_UK
dc.publisherNational Institute for Health and Care Researchen_UK
dc.relationMcCulloch P, Shaw A, Gilchrist G, Matheson C, Maxwell M, Neale J, Myring G, McLeod H, Hickman M, Vickerman P, Munro A & MacGillivray S (2025) Optimal provision of opiate substitution therapy and needle and syringe programmes: a multi-method realist evaluation. <i>Health Technology Assessment</i>, 29 (64). https://doi.org/10.3310/hgds4449en_UK
dc.rightsCopyright © 2025 McCulloch et al. This work was produced by McCulloch et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This is an Open Access publication distributed under the terms of the Creative Commons Attribution CC BY 4.0 licence, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. See: https://creativecommons.org/licenses/by/4.0/. For attribution the title, original author(s), the publication source – NIHR Journals Library, and the DOI of the publication must be cited.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.titleOptimal provision of opiate substitution therapy and needle and syringe programmes: a multi-method realist evaluationen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.3310/hgds4449en_UK
dc.identifier.pmid41358558en_UK
dc.citation.jtitleHealth Technology Assessmenten_UK
dc.citation.issn1366-5278en_UK
dc.citation.volume29en_UK
dc.citation.issue64en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderNational Institute for Health Researchen_UK
dc.author.emailcatriona.matheson@stir.ac.uken_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationFaculty of Social Sciencesen_UK
dc.contributor.affiliationKing's College Londonen_UK
dc.contributor.affiliationCHeCRen_UK
dc.contributor.affiliationCHeCRen_UK
dc.contributor.affiliationKing's College Londonen_UK
dc.contributor.affiliationUniversity of Bristolen_UK
dc.contributor.affiliationUniversity of Bristolen_UK
dc.contributor.affiliationUniversity of Bristolen_UK
dc.contributor.affiliationUniversity of Bristolen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.identifier.isiWOS:001636060500001en_UK
dc.identifier.scopusid105024145614en_UK
dc.identifier.wtid2218252en_UK
dc.contributor.orcid0009-0005-4241-5735en_UK
dc.contributor.orcid0009-0001-4987-0555en_UK
dc.contributor.orcid0000-0002-5616-6283en_UK
dc.contributor.orcid0000-0003-3318-9500en_UK
dc.contributor.orcid0000-0003-1502-5983en_UK
dc.contributor.orcid0000-0002-7811-2091en_UK
dc.contributor.orcid0000-0002-2266-7303en_UK
dc.contributor.orcid0000-0001-9864-459Xen_UK
dc.contributor.orcid0000-0002-8291-5890en_UK
dc.contributor.orcid0000-0002-2350-8128en_UK
dc.contributor.orcid0000-0002-1933-6431en_UK
dc.date.accepted2025-12-10en_UK
dcterms.dateAccepted2025-12-10en_UK
dc.date.filedepositdate2025-12-11en_UK
dc.relation.funderprojectUnderstanding the contextual factors that impact on the effective provision of opiate substitution therapy (OST) and needle and syringe programmes (NSP) in the UK: a multi-method study and realist evaluation of what works, for whom and under what circumstancesen_UK
dc.relation.funderrefNIHR129798en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorMcCulloch, Peter|0009-0005-4241-5735en_UK
local.rioxx.authorShaw, April|0009-0001-4987-0555en_UK
local.rioxx.authorGilchrist, Gail|0000-0002-5616-6283en_UK
local.rioxx.authorMatheson, Catriona|en_UK
local.rioxx.authorMaxwell, Margaret|0000-0003-3318-9500en_UK
local.rioxx.authorNeale, Joanne|0000-0003-1502-5983en_UK
local.rioxx.authorMyring, Gareth|0000-0002-7811-2091en_UK
local.rioxx.authorMcLeod, Hugh|0000-0002-2266-7303en_UK
local.rioxx.authorHickman, Matt|0000-0001-9864-459Xen_UK
local.rioxx.authorVickerman, Peter|0000-0002-8291-5890en_UK
local.rioxx.authorMunro, Alison|0000-0002-2350-8128en_UK
local.rioxx.authorMacGillivray, Steve|0000-0002-1933-6431en_UK
local.rioxx.projectNIHR129798|National Institute for Health Research|http://dx.doi.org/10.13039/501100000272en_UK
local.rioxx.freetoreaddate2026-01-21en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2026-01-21|en_UK
local.rioxx.filename3049364.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1366-5278en_UK
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