Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/36417
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dc.contributor.authorLee, Boheeen_UK
dc.contributor.authorLewis, Graceen_UK
dc.contributor.authorAgyei-Manu, Eldaden_UK
dc.contributor.authorAtkins, Nadegeen_UK
dc.contributor.authorBhattacharyya, Urmilaen_UK
dc.contributor.authorDozier, Marshallen_UK
dc.contributor.authorRostron, Jasminen_UK
dc.contributor.authorSheikh, Azizen_UK
dc.contributor.authorMcQuillan, Ruthen_UK
dc.contributor.authorTheodoratou, Evropien_UK
dc.date.accessioned2024-11-06T01:05:37Z-
dc.date.available2024-11-06T01:05:37Z-
dc.date.issued2022-12-31en_UK
dc.identifier.other220066en_UK
dc.identifier.urihttp://hdl.handle.net/1893/36417-
dc.description.abstractBackground The Joint Committee on Vaccination and Immunisation in the United Kingdom requested an evidence synthesis to investigate the relationship between asthma and coronavirus disease 2019 (COVID-19) outcomes. Objective We conducted a systematic review and meta-analysis to summarise evidence on the risk of severe COVID-19 outcomes in people with uncontrolled asthma or markers of asthma severity. Methods High-dose inhaled corticosteroids (ICS) or oral corticosteroids (OCS) were used as markers of asthma severity, following international or national asthma guidelines. Risk of bias was assessed using Joanna Briggs Institute tools. Adjusted point estimates were extracted for random-effects meta-analyses and subgroup analyses. Results After screening, 12 studies (11 in adults and one in children) met the eligibility criteria. Adults using high-dose ICS or OCS had a pooled adjusted hazard ratio (aHR) of 1.33 (95% CI 1.06–1.67, I2=0%) for hospitalisation and an aHR of 1.22 (95% CI 0.90–1.65, I2=70%) for mortality for COVID-19. We found insufficient evidence for associations between markers on COVID-19 mortality in the subgroup analyses. Conclusions Adults with severe asthma are at increased risk of COVID-19 hospitalisation compared to nonusers. Our analysis highlighted the dearth of studies in children with asthma investigating serious COVID-19 outcomes.en_UK
dc.language.isoenen_UK
dc.publisherEuropean Respiratory Society (ERS)en_UK
dc.relationLee B, Lewis G, Agyei-Manu E, Atkins N, Bhattacharyya U, Dozier M, Rostron J, Sheikh A, McQuillan R & Theodoratou E (2022) Risk of serious COVID-19 outcomes among adults and children with moderate-to-severe asthma: a systematic review and meta-analysis. <i>European Respiratory Review</i>, 31 (166), Art. No.: 220066. https://doi.org/10.1183/16000617.0066-2022en_UK
dc.rightsCopyright ©The authors 2022 This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.orgen_UK
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en_UK
dc.titleRisk of serious COVID-19 outcomes among adults and children with moderate-to-severe asthma: a systematic review and meta-analysisen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1183/16000617.0066-2022en_UK
dc.identifier.pmid36323417en_UK
dc.citation.jtitleEuropean Respiratory Reviewen_UK
dc.citation.issn1600-0617en_UK
dc.citation.issn0905-9180en_UK
dc.citation.volume31en_UK
dc.citation.issue166en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderThe Wellcome Trusten_UK
dc.author.emailg.m.lewis@stir.ac.uken_UK
dc.citation.date02/11/2022en_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.identifier.isiWOS:000922536500001en_UK
dc.identifier.scopusid2-s2.0-85141186032en_UK
dc.identifier.wtid2057045en_UK
dc.contributor.orcid0000-0002-9671-386Xen_UK
dc.contributor.orcid0000-0002-5282-2941en_UK
dc.contributor.orcid0000-0002-2712-0198en_UK
dc.contributor.orcid0000-0003-0089-2937en_UK
dc.contributor.orcid0000-0003-2316-7359en_UK
dc.contributor.orcid0000-0002-5151-1252en_UK
dc.contributor.orcid0000-0003-2960-2892en_UK
dc.contributor.orcid0000-0001-7022-3056en_UK
dc.contributor.orcid0000-0003-0998-9540en_UK
dc.contributor.orcid0000-0001-5887-9132en_UK
dc.date.accepted2022-07-31en_UK
dcterms.dateAccepted2022-07-31en_UK
dc.date.filedepositdate2024-10-17en_UK
dc.subject.tagCOVID-19en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorLee, Bohee|0000-0002-9671-386Xen_UK
local.rioxx.authorLewis, Grace|0000-0002-5282-2941en_UK
local.rioxx.authorAgyei-Manu, Eldad|0000-0002-2712-0198en_UK
local.rioxx.authorAtkins, Nadege|0000-0003-0089-2937en_UK
local.rioxx.authorBhattacharyya, Urmila|0000-0003-2316-7359en_UK
local.rioxx.authorDozier, Marshall|0000-0002-5151-1252en_UK
local.rioxx.authorRostron, Jasmin|0000-0003-2960-2892en_UK
local.rioxx.authorSheikh, Aziz|0000-0001-7022-3056en_UK
local.rioxx.authorMcQuillan, Ruth|0000-0003-0998-9540en_UK
local.rioxx.authorTheodoratou, Evropi|0000-0001-5887-9132en_UK
local.rioxx.projectProject ID unknown|The Wellcome Trust|en_UK
local.rioxx.freetoreaddate2024-10-31en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by-nc/4.0/|2024-10-31|en_UK
local.rioxx.filename220066.full.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1600-0617en_UK
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