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http://hdl.handle.net/1893/36417
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DC Field | Value | Language |
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dc.contributor.author | Lee, Bohee | en_UK |
dc.contributor.author | Lewis, Grace | en_UK |
dc.contributor.author | Agyei-Manu, Eldad | en_UK |
dc.contributor.author | Atkins, Nadege | en_UK |
dc.contributor.author | Bhattacharyya, Urmila | en_UK |
dc.contributor.author | Dozier, Marshall | en_UK |
dc.contributor.author | Rostron, Jasmin | en_UK |
dc.contributor.author | Sheikh, Aziz | en_UK |
dc.contributor.author | McQuillan, Ruth | en_UK |
dc.contributor.author | Theodoratou, Evropi | en_UK |
dc.date.accessioned | 2024-11-06T01:05:37Z | - |
dc.date.available | 2024-11-06T01:05:37Z | - |
dc.date.issued | 2022-12-31 | en_UK |
dc.identifier.other | 220066 | en_UK |
dc.identifier.uri | http://hdl.handle.net/1893/36417 | - |
dc.description.abstract | Background The Joint Committee on Vaccination and Immunisation in the United Kingdom requested an evidence synthesis to investigate the relationship between asthma and coronavirus disease 2019 (COVID-19) outcomes. Objective We conducted a systematic review and meta-analysis to summarise evidence on the risk of severe COVID-19 outcomes in people with uncontrolled asthma or markers of asthma severity. Methods High-dose inhaled corticosteroids (ICS) or oral corticosteroids (OCS) were used as markers of asthma severity, following international or national asthma guidelines. Risk of bias was assessed using Joanna Briggs Institute tools. Adjusted point estimates were extracted for random-effects meta-analyses and subgroup analyses. Results After screening, 12 studies (11 in adults and one in children) met the eligibility criteria. Adults using high-dose ICS or OCS had a pooled adjusted hazard ratio (aHR) of 1.33 (95% CI 1.06–1.67, I2=0%) for hospitalisation and an aHR of 1.22 (95% CI 0.90–1.65, I2=70%) for mortality for COVID-19. We found insufficient evidence for associations between markers on COVID-19 mortality in the subgroup analyses. Conclusions Adults with severe asthma are at increased risk of COVID-19 hospitalisation compared to nonusers. Our analysis highlighted the dearth of studies in children with asthma investigating serious COVID-19 outcomes. | en_UK |
dc.language.iso | en | en_UK |
dc.publisher | European Respiratory Society (ERS) | en_UK |
dc.relation | Lee B, Lewis G, Agyei-Manu E, Atkins N, Bhattacharyya U, Dozier M, Rostron J, Sheikh A, McQuillan R & Theodoratou E (2022) Risk of serious COVID-19 outcomes among adults and children with moderate-to-severe asthma: a systematic review and meta-analysis. <i>European Respiratory Review</i>, 31 (166), Art. No.: 220066. https://doi.org/10.1183/16000617.0066-2022 | en_UK |
dc.rights | Copyright ©The authors 2022 This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org | en_UK |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | en_UK |
dc.title | Risk of serious COVID-19 outcomes among adults and children with moderate-to-severe asthma: a systematic review and meta-analysis | en_UK |
dc.type | Journal Article | en_UK |
dc.identifier.doi | 10.1183/16000617.0066-2022 | en_UK |
dc.identifier.pmid | 36323417 | en_UK |
dc.citation.jtitle | European Respiratory Review | en_UK |
dc.citation.issn | 1600-0617 | en_UK |
dc.citation.issn | 0905-9180 | en_UK |
dc.citation.volume | 31 | en_UK |
dc.citation.issue | 166 | en_UK |
dc.citation.publicationstatus | Published | en_UK |
dc.citation.peerreviewed | Refereed | en_UK |
dc.type.status | VoR - Version of Record | en_UK |
dc.contributor.funder | The Wellcome Trust | en_UK |
dc.author.email | g.m.lewis@stir.ac.uk | en_UK |
dc.citation.date | 02/11/2022 | en_UK |
dc.contributor.affiliation | University of Edinburgh | en_UK |
dc.contributor.affiliation | University of Edinburgh | en_UK |
dc.contributor.affiliation | University of Edinburgh | en_UK |
dc.contributor.affiliation | University of Edinburgh | en_UK |
dc.contributor.affiliation | University of Edinburgh | en_UK |
dc.contributor.affiliation | University of Edinburgh | en_UK |
dc.contributor.affiliation | University of Edinburgh | en_UK |
dc.contributor.affiliation | University of Edinburgh | en_UK |
dc.contributor.affiliation | University of Edinburgh | en_UK |
dc.contributor.affiliation | University of Edinburgh | en_UK |
dc.identifier.isi | WOS:000922536500001 | en_UK |
dc.identifier.scopusid | 2-s2.0-85141186032 | en_UK |
dc.identifier.wtid | 2057045 | en_UK |
dc.contributor.orcid | 0000-0002-9671-386X | en_UK |
dc.contributor.orcid | 0000-0002-5282-2941 | en_UK |
dc.contributor.orcid | 0000-0002-2712-0198 | en_UK |
dc.contributor.orcid | 0000-0003-0089-2937 | en_UK |
dc.contributor.orcid | 0000-0003-2316-7359 | en_UK |
dc.contributor.orcid | 0000-0002-5151-1252 | en_UK |
dc.contributor.orcid | 0000-0003-2960-2892 | en_UK |
dc.contributor.orcid | 0000-0001-7022-3056 | en_UK |
dc.contributor.orcid | 0000-0003-0998-9540 | en_UK |
dc.contributor.orcid | 0000-0001-5887-9132 | en_UK |
dc.date.accepted | 2022-07-31 | en_UK |
dcterms.dateAccepted | 2022-07-31 | en_UK |
dc.date.filedepositdate | 2024-10-17 | en_UK |
dc.subject.tag | COVID-19 | en_UK |
rioxxterms.apc | not required | en_UK |
rioxxterms.type | Journal Article/Review | en_UK |
rioxxterms.version | VoR | en_UK |
local.rioxx.author | Lee, Bohee|0000-0002-9671-386X | en_UK |
local.rioxx.author | Lewis, Grace|0000-0002-5282-2941 | en_UK |
local.rioxx.author | Agyei-Manu, Eldad|0000-0002-2712-0198 | en_UK |
local.rioxx.author | Atkins, Nadege|0000-0003-0089-2937 | en_UK |
local.rioxx.author | Bhattacharyya, Urmila|0000-0003-2316-7359 | en_UK |
local.rioxx.author | Dozier, Marshall|0000-0002-5151-1252 | en_UK |
local.rioxx.author | Rostron, Jasmin|0000-0003-2960-2892 | en_UK |
local.rioxx.author | Sheikh, Aziz|0000-0001-7022-3056 | en_UK |
local.rioxx.author | McQuillan, Ruth|0000-0003-0998-9540 | en_UK |
local.rioxx.author | Theodoratou, Evropi|0000-0001-5887-9132 | en_UK |
local.rioxx.project | Project ID unknown|The Wellcome Trust| | en_UK |
local.rioxx.freetoreaddate | 2024-10-31 | en_UK |
local.rioxx.licence | http://creativecommons.org/licenses/by-nc/4.0/|2024-10-31| | en_UK |
local.rioxx.filename | 220066.full.pdf | en_UK |
local.rioxx.filecount | 1 | en_UK |
local.rioxx.source | 1600-0617 | en_UK |
Appears in Collections: | Faculty of Health Sciences and Sport Journal Articles |
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220066.full.pdf | Fulltext - Published Version | 989.51 kB | Adobe PDF | View/Open |
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