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dc.contributor.authorMcFarland, Agien_UK
dc.contributor.authorManoukian, Sarkisen_UK
dc.contributor.authorMason, Helenen_UK
dc.contributor.authorReilly, Jacqui Sen_UK
dc.description.abstractBackground: SSI are recognised as negatively affecting patient quality of life. Currently, no meta-analysis of SSI utility values is available in the literature to inform estimates of this burden and investment decisions in prevention. Method: A systematic search of PubMed, Medline, CINAHL and the NHS Economic Evaluation Database was performed in April 2022 as per PROSPERO registration CRD 42021262633. Studies were included where quality of life data was gathered from adults undergoing surgery whereby quality of life data was presented as those with infection and those without at similar time points. Two researchers performed data extraction and quality appraisal independently, with a third as arbiter. Utility values were converted to EQ-5D. Meta-analyses were conducted using a random effects model across all relevant studies with subgroup analyses on SSI type and timing since surgery. Results: 15 studies met the inclusion criteria with 2817 patients; six studies across seven time points were used for meta-analysis. The pooled mean difference in EQ-5D utility in all studies combined was – 0.08 (95% CI -0.11 - -0.05, I2 = 40%, prediction interval -0.16 to -0.01.). The mean difference in EQ-5D utility associated with Deep SSI was -0.10 (95%CI -0.14 - -0.06, I2 = 0.00%) and the mean difference in EQ-5D persisted over time. Conclusion: The first synthesised estimate of SSI burden over the short and long term is provided. EQ-5D utility estimates for a range of SSI are essential for infection prevention planning and future economic modelling.en_UK
dc.relationMcFarland A, Manoukian S, Mason H & Reilly JS (2023) The impact of surgical-site infection on health utility values: a meta-analysis. <i>British Journal of Surgery</i>.
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en_UK
dc.subjectSurgical site infectionen_UK
dc.subjecthealth related quality of lifeen_UK
dc.subjectmeta analysisen_UK
dc.titleThe impact of surgical-site infection on health utility values: a meta-analysisen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleBritish Journal of Surgeryen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderGlasgow Caledonian Universityen_UK
dc.description.notesI am uploading the PDF of the accepted manuscript and will update it with the PDF proof once availableen_UK
dc.contributor.affiliationHealth Sciences Stirlingen_UK
dc.contributor.affiliationGlasgow Caledonian Universityen_UK
dc.contributor.affiliationGlasgow Caledonian Universityen_UK
dc.contributor.affiliationGlasgow Caledonian Universityen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorMcFarland, Agi|0000-0002-5061-273Xen_UK
local.rioxx.authorManoukian, Sarkis|en_UK
local.rioxx.authorMason, Helen|en_UK
local.rioxx.authorReilly, Jacqui S|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.projectProject ID unknown|Glasgow Caledonian University|
local.rioxx.filenameMcFarland 2023.pdfen_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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