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dc.contributor.authorYusof, Muhammad Zubiren_UK
dc.contributor.authorCherrie, John Wen_UK
dc.contributor.authorSamsuddin, Nizaen_UK
dc.contributor.authorSemple, Seanen_UK
dc.description.abstractBackground Use of pesticides has been linked to neurobehavioral deficits among exposed workers. In Malaysia, organophosphate and pyrethroid pesticides are commonly used to control mosquito-borne diseases. Objectives This study aims to assess workers’ lifetime occupational pesticide exposure and examine the relationship with neurobehavioral health. Methods A cross-sectional study was conducted on 158 pesticide-exposed and 176 non-exposed workers. To collect historical exposure and job tasks, a questionnaire and an occupational history interview were used. Pesticide exposure was measured in a subgroup of workers via inhalation and skin contact. The total pesticide intake of each worker was assessed using inhalation and dermal exposure models. CANTAB® computerised neurobehavioral performance assessments were used. Results The participants’ mean age was 31 (8) years. Pirimiphos-methyl (median = 0.569 mg/m3, Interquartile range [IQR] = 0.151, 0.574) and permethrin (median = 0.136 mg/m3, IQR = 0.116, 0.157) had the highest measured personal inhalation concentrations during thermal spraying. The estimated total lifetime pesticide intake for exposed workers ranged from 0.006 g to 12800 g (median = 379 g and IQR = 131, 794 g). Dermal exposure was the predominant route of pesticide intake for all workers. Compared to controls, workers with high lifetime pesticide intake had lower Match to Sample Visual (adjusted B = −1.4, 95% Confidence Interval (CI) = −2.6, 0.1), Spatial Recognition Memory (adjusted B = −3.3, 95% CI = −5.8, 0.8), Spatial Span (SSP) (adjusted B = −0.6, 95% CI = −0.9, 0.3) scores. Workers with low pesticide intake performed worse than controls (adjusted B = −0.5, 95% CI = −0.8, −0.2) in the SSP test, but scored higher in the Motor Screening test (adjusted B = 0.9, 95% CI = 0.1, 1.6). Higher Paired Associates Learning test scores were observed among higher (adjusted B = 7.4, 95% CI = 2.3, 12.4) and lower (adjusted B = 8.1, 95% CI = 3, 13.2) pesticide intake groups. There was no significant difference between the Reaction Time and Pattern Recognition Memory tests with lifetime pesticide intake after adjusting for confounders. Conclusion Pesticide exposure has been linked to poorer neurobehavioral performance. As dermal exposure accounts for a major fraction of total intake, pesticide prevention should focus on limiting dermal exposure.en_UK
dc.publisherOxford University Press (OUP)en_UK
dc.relationYusof MZ, Cherrie JW, Samsuddin N & Semple S (2022) Mosquito Control Workers in Malaysia: Is Lifetime Occupational Pesticide Exposure Associated With Poorer Neurobehavioral Performance?. Annals of Work Exposures and Health.
dc.rightsThis item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. This is a pre-copyedited, author-produced PDF of an article accepted for publication in Annals of Work Exposures and Health following peer review. The version of record Yusof MZ, Cherrie JW, Samsuddin N & Semple S (2022) Mosquito Control Workers in Malaysia: Is Lifetime Occupational Pesticide Exposure Associated With Poorer Neurobehavioral Performance?. Annals of Work Exposures and Health is available online at:
dc.titleMosquito Control Workers in Malaysia: Is Lifetime Occupational Pesticide Exposure Associated With Poorer Neurobehavioral Performance?en_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[Yusof et al 2022 AAM_main.pdf] Publisher requires embargo of 12 months after publication.en_UK
dc.citation.jtitleAnnals of Work Exposures and Healthen_UK
dc.type.statusNA - Not Applicable (or Unknown)en_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.contributor.funderMinistry of Higher Education, Malaysiaen_UK
dc.description.notesOutput Status: Forthcoming/Available Onlineen_UK
dc.contributor.affiliationInternational Islamic University of Malaysiaen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationInternational Islamic University of Malaysiaen_UK
dc.contributor.affiliationInstitute for Social Marketingen_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorYusof, Muhammad Zubir|0000-0003-2610-146Xen_UK
local.rioxx.authorCherrie, John W|en_UK
local.rioxx.authorSamsuddin, Niza|en_UK
local.rioxx.authorSemple, Sean|0000-0002-0462-7295en_UK
local.rioxx.projectProject ID unknown|Ministry of Higher Education, Malaysia|en_UK
local.rioxx.filenameYusof et al 2022 AAM_main.pdfen_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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