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Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/34151
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dc.contributor.authorHajek, Peteren_UK
dc.contributor.authorPrzulj, Dunjaen_UK
dc.contributor.authorPesola, Francescaen_UK
dc.contributor.authorGriffiths, Christopheren_UK
dc.contributor.authorWalton, Roberten_UK
dc.contributor.authorMcRobbie, Haydenen_UK
dc.contributor.authorColeman, Timen_UK
dc.contributor.authorLewis, Sarahen_UK
dc.contributor.authorWhitemore, Rachelen_UK
dc.contributor.authorClark, Mirandaen_UK
dc.contributor.authorUssher, Michaelen_UK
dc.contributor.authorSinclair, Lesleyen_UK
dc.contributor.authorSeager, Emilieen_UK
dc.contributor.authorCooper, Sueen_UK
dc.contributor.authorBauld, Lindaen_UK
dc.contributor.authorNaughton, Felixen_UK
dc.contributor.authorSaseni, Peteren_UK
dc.contributor.authorManyonda, Isaacen_UK
dc.contributor.authorMyers Smith, Katieen_UK
dc.date.accessioned2022-04-12T00:01:39Z-
dc.date.available2022-04-12T00:01:39Z-
dc.identifier.urihttp://hdl.handle.net/1893/34151-
dc.description.abstractNicotine replacement therapy is commonly offered to pregnant women who smoke to help them quit, but it has limited efficacy in this group. E-cigarettes are also used by pregnant smokers, but their safety and efficacy in pregnancy are unknown. Here we report the results of comparing nicotine patches with refillable e-cigarettes in a randomised controlled trial involving 1,140 participants. In the unadjusted primary analysis, validated prolonged quit rates at the end of pregnancy in the two study arms were not significantly different, but some abstainers in the patch arm used e-cigarettes. In a pre-specified sensitivity analysis excluding abstainers using non-allocated products, e-cigarettes were markedly more effective than patches.Low birthweight (en_UK
dc.language.isoenen_UK
dc.publisherNature Publishing Groupen_UK
dc.relationHajek P, Przulj D, Pesola F, Griffiths C, Walton R, McRobbie H, Coleman T, Lewis S, Whitemore R, Clark M, Ussher M, Sinclair L, Seager E, Cooper S, Bauld L, Naughton F, Saseni P, Manyonda I & Myers Smith K (2022) Safety and efficacy of e-cigarettes versus nicotine patches when used to help pregnant smokers quit. A randomised controlled trial. <i>Nature Medicine</i>.en_UK
dc.rightsThis item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.titleSafety and efficacy of e-cigarettes versus nicotine patches when used to help pregnant smokers quit. A randomised controlled trialen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2024-09-30en_UK
dc.rights.embargoreason[Hajek_2022-Nature Medicine (1).pdf] Publisher requires embargo of 6 months after publication.en_UK
dc.citation.jtitleNature Medicineen_UK
dc.citation.issn1546-170Xen_UK
dc.citation.issn1078-8956en_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.contributor.funderNational Institute for Health Researchen_UK
dc.author.emailaileen.paton@stir.ac.uken_UK
dc.description.notesOutput Status: Forthcomingen_UK
dc.contributor.affiliationQueen Mary, University of Londonen_UK
dc.contributor.affiliationQueen Mary, University of Londonen_UK
dc.contributor.affiliationQueen Mary, University of Londonen_UK
dc.contributor.affiliationQueen Mary, University of Londonen_UK
dc.contributor.affiliationQueen Mary, University of Londonen_UK
dc.contributor.affiliationQueen Mary, University of Londonen_UK
dc.contributor.affiliationUniversity of Nottinghamen_UK
dc.contributor.affiliationUniversity of Nottinghamen_UK
dc.contributor.affiliationUniversity of Nottinghamen_UK
dc.contributor.affiliationUniversity of Nottinghamen_UK
dc.contributor.affiliationInstitute for Social Marketingen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationQueen Mary, University of Londonen_UK
dc.contributor.affiliationUniversity of Nottinghamen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of East Angliaen_UK
dc.contributor.affiliationKing's College Londonen_UK
dc.contributor.affiliationSt George's University Hospitals NHSen_UK
dc.contributor.affiliationQueen Mary, University of Londonen_UK
dc.identifier.wtid1808841en_UK
dc.contributor.orcid0000-0002-0995-7955en_UK
dc.date.accepted2022-03-31en_UK
dcterms.dateAccepted2022-03-31en_UK
dc.date.filedepositdate2022-04-11en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.versionAMen_UK
local.rioxx.authorHajek, Peter|en_UK
local.rioxx.authorPrzulj, Dunja|en_UK
local.rioxx.authorPesola, Francesca|en_UK
local.rioxx.authorGriffiths, Christopher|en_UK
local.rioxx.authorWalton, Robert|en_UK
local.rioxx.authorMcRobbie, Hayden|en_UK
local.rioxx.authorColeman, Tim|en_UK
local.rioxx.authorLewis, Sarah|en_UK
local.rioxx.authorWhitemore, Rachel|en_UK
local.rioxx.authorClark, Miranda|en_UK
local.rioxx.authorUssher, Michael|0000-0002-0995-7955en_UK
local.rioxx.authorSinclair, Lesley|en_UK
local.rioxx.authorSeager, Emilie|en_UK
local.rioxx.authorCooper, Sue|en_UK
local.rioxx.authorBauld, Linda|en_UK
local.rioxx.authorNaughton, Felix|en_UK
local.rioxx.authorSaseni, Peter|en_UK
local.rioxx.authorManyonda, Isaac|en_UK
local.rioxx.authorMyers Smith, Katie|en_UK
local.rioxx.projectProject ID unknown|National Institute for Health Research|http://dx.doi.org/10.13039/501100000272en_UK
local.rioxx.freetoreaddate2024-09-30en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||2024-09-29en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/all-rights-reserved|2024-09-30|en_UK
local.rioxx.filenameHajek_2022-Nature Medicine (1).pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1546-170Xen_UK
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