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Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: The Emerging Role of Interleukin 1β (IL-1β) in Cancer Cachexia
Author(s): Laird, Barry J
McMillan, Donald
Skipworth, Richard J E
Fallon, Marie T
Paval, D Robert
McNeish, Iain
Gallagher, Iain J
Keywords: Inflammation
Interleukin-1 beta
Issue Date: Aug-2021
Date Deposited: 25-May-2021
Citation: Laird BJ, McMillan D, Skipworth RJE, Fallon MT, Paval DR, McNeish I & Gallagher IJ (2021) The Emerging Role of Interleukin 1β (IL-1β) in Cancer Cachexia. Inflammation, 44 (4), pp. 1223-1228.
Abstract: Treatment of cancer cachexia remains an unmet need. The host-tumour interface and the resulting sequestration of the pro-inflammatory cytokine Il-1β is critical in cachexia development. Neuroinflammation mediated via IL-1β through the hypothalamic pituitary axis results in increased muscle proteolysis and adipose lipolysis, thus creating a prolonged stress-like environment with loss of appetite and increased resting energy expenditure. Recent trials using a monoclonal antibody targeting IL-1β, canakinumab, have shown a potential role in lung cancer; however, a potential role of targeting IL-1β to treat cachexia in patients with lung cancer is unclear, yet the underlying pathophysiology provides a sound rationale that this may be a viable therapeutic approach.
DOI Link: 10.1007/s10753-021-01429-8
Rights: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit
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