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Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/32253
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dc.contributor.authorPatton, Rebekahen_UK
dc.contributor.authorPaval, D Roberten_UK
dc.contributor.authorMcDonald, James Jen_UK
dc.contributor.authorBrown, Duncanen_UK
dc.contributor.authorGallagher, Iain Jen_UK
dc.contributor.authorSkipworth, Richard J Een_UK
dc.contributor.authorMcMillan, Donald Cen_UK
dc.contributor.authorDolan, Ross Den_UK
dc.contributor.authorFallon, Marieen_UK
dc.contributor.authorLaird, Barry J Aen_UK
dc.date.accessioned2021-02-09T01:02:46Z-
dc.date.available2021-02-09T01:02:46Z-
dc.date.issued2021-03en_UK
dc.identifier.other103222en_UK
dc.identifier.urihttp://hdl.handle.net/1893/32253-
dc.description.abstractBackground Development and spread of cancer is linked to the inflammatory response, in which cytokines serve a key role. The inflammatory response may also form the basis for symptoms of cancer. This systematic review examines the relationship between cytokines and symptoms in incurable cancer. Methods MEDLINE, EMBASE, Cochrane Library, CINAHL, Web of Science and PsycINFO databases were searched for studies from January 2004 to January 2020. Results Twenty studies were selected (n = 1806 patients, 119 controls). Symptoms studied included depression, fatigue, pain, and loss of appetite. Nine studies examined patients with a specified tumour type, the remainder included patients with a mix of tumour types. Thirty-one cytokines were examined; multiple associations between cytokines and symptoms were described, supporting the hypothesis that cytokines may have a key role in symptom generation. Conclusion Symptoms of incurable cancer are associated with circulating cytokines. Further study is required to characterise these relationships, and to explore their therapeutic potential.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationPatton R, Paval DR, McDonald JJ, Brown D, Gallagher IJ, Skipworth RJE, McMillan DC, Dolan RD, Fallon M & Laird BJA (2021) Relationship between cytokines and symptoms in people with incurable cancer: A systematic review. Critical Reviews in Oncology/Hematology, 159, Art. No.: 103222. https://doi.org/10.1016/j.critrevonc.2021.103222en_UK
dc.rightsThis item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Accepted refereed manuscript of: Patton R, Paval DR, McDonald JJ, Brown D, Gallagher IJ, Skipworth RJE, McMillan DC, Dolan RD, Fallon M & Laird BJA (2021) Relationship between cytokines and symptoms in people with incurable cancer: A systematic review. Critical Reviews in Oncology/Hematology, 159, Art. No.: 103222. https://doi.org/10.1016/j.critrevonc.2021.103222 © 2021, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/en_UK
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_UK
dc.subjectCytokinesen_UK
dc.subjectPalliative medicineen_UK
dc.subjectSymptomsen_UK
dc.subjectSystemic inflammatory responseen_UK
dc.subjectCanceren_UK
dc.titleRelationship between cytokines and symptoms in people with incurable cancer: A systematic reviewen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2022-01-20en_UK
dc.rights.embargoreason[Patton-etal-CROH-2021.pdf] Publisher requires embargo of 12 months after formal publication.en_UK
dc.identifier.doi10.1016/j.critrevonc.2021.103222en_UK
dc.identifier.pmid33482344en_UK
dc.citation.jtitleCritical Reviews in Oncology/Hematologyen_UK
dc.citation.issn1040-8428en_UK
dc.citation.volume159en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.author.emaili.j.gallagher@stir.ac.uken_UK
dc.citation.date19/01/2021en_UK
dc.contributor.affiliationSt Columba's Hospiceen_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationNinewells Hospital & Medical Schoolen_UK
dc.contributor.affiliationSt Columba's Hospiceen_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationRoyal Infirmary of Edinburghen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationSt Columba's Hospiceen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.identifier.isiWOS:000625372500007en_UK
dc.identifier.scopusid2-s2.0-85100432354en_UK
dc.identifier.wtid1702782en_UK
dc.contributor.orcid0000-0002-5719-7591en_UK
dc.contributor.orcid0000-0002-8630-7235en_UK
dc.date.accepted2021-01-16en_UK
dcterms.dateAccepted2021-01-16en_UK
dc.date.filedepositdate2021-02-08en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorPatton, Rebekah|en_UK
local.rioxx.authorPaval, D Robert|0000-0002-5719-7591en_UK
local.rioxx.authorMcDonald, James J|en_UK
local.rioxx.authorBrown, Duncan|en_UK
local.rioxx.authorGallagher, Iain J|0000-0002-8630-7235en_UK
local.rioxx.authorSkipworth, Richard J E|en_UK
local.rioxx.authorMcMillan, Donald C|en_UK
local.rioxx.authorDolan, Ross D|en_UK
local.rioxx.authorFallon, Marie|en_UK
local.rioxx.authorLaird, Barry J A|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2022-01-20en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||2022-01-19en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by-nc-nd/4.0/|2022-01-20|en_UK
local.rioxx.filenamePatton-etal-CROH-2021.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1040-8428en_UK
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