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dc.contributor.authorGalloway, S D-
dc.contributor.authorTalanian, Jason L-
dc.contributor.authorShoveller, Anna K-
dc.contributor.authorHeigenhauser, George J F-
dc.contributor.authorSpriet, Lawrence L-
dc.description.abstractThis study examined 1) the plasma taurine response to acute oral taurine supplementation (T), and 2) the effects of 7 days (d) of T on muscle amino acid content and substrate metabolism during 2 hr of cycling at ~60% VO2peak. 1) After an overnight fast seven volunteers (28±3yr, 184±2cm, 88.0±6.6kg) ingested 1.66g oral taurine doses with breakfast (8AM) and lunch (12noon) and blood samples were taken throughout the day. 2) Eight males (22±1yr, 181±1cm, 80.9±3.8kg, 4.21±0.16L.min-1 VO2peak) cycled for 2hr after 7d of placebo (P) ingestion (6g glucose/d) and again following 7d of T (5g/d). 1) Plasma taurine was 64±4µM prior to T and rose rapidly to 778±139µM by 10AM and remained elevated at noon (359±56µM). Plasma taurine reached 973±181µM at 1PM and was 161±31µM at 4PM. 2) Seven days of T had no effect on muscle taurine content (mmol/kg dry muscle) at rest (P, 44±15 vs. T, 42±15) or after exercise (P, 43±12 vs. T, 43±11). There was no difference in muscle glycogen or other muscle metabolites between conditions, but there were notable increases in muscle indispensable amino acid content following exercise after T. These data indicate that 1) acute T produces a 13 fold increase in plasma taurine concentration, 2) despite the ability to significantly elevate plasma taurine for extended periods throughout the day, 7 days of T does not alter skeletal muscle taurine content or carbohydrate and fat oxidation during exercise, and 3) T appears to alter muscle indispensable amino acid response to exercise.en_UK
dc.publisherAmerican Physiological Society-
dc.relationGalloway SD, Talanian JL, Shoveller AK, Heigenhauser GJF & Spriet LL (2008) Seven days of oral taurine supplementation does not increase muscle taurine content or alter substrate metabolism during prolonged exercise in humans, Journal of Applied Physiology, 105 (2), pp. 643-651.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author; you can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectamino acidsen_UK
dc.subjectmuscle glycogenen_UK
dc.subject.lcshAthletes Nutrition-
dc.subject.lcshTaurine Physiological effect-
dc.subject.lcshSports Medicine methods-
dc.titleSeven days of oral taurine supplementation does not increase muscle taurine content or alter substrate metabolism during prolonged exercise in humansen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.citation.jtitleJournal of Applied Physiology-
dc.type.statusPost-print (author final draft post-refereeing)-
dc.contributor.affiliationUniversity of Guelph-
dc.contributor.affiliationUniversity of Guelph-
dc.contributor.affiliationMcMaster University-
dc.contributor.affiliationUniversity of Guelph-
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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