Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/31157
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dc.contributor.authorBurley, Claire Ven_UK
dc.contributor.authorLucas, Rebekah A Ien_UK
dc.contributor.authorWhittaker, Anna Cen_UK
dc.contributor.authorMullinger, Karenen_UK
dc.contributor.authorLucas, Samuel J Een_UK
dc.date.accessioned2020-05-16T00:01:54Z-
dc.date.available2020-05-16T00:01:54Z-
dc.date.issued2020-05-01en_UK
dc.identifier.urihttp://hdl.handle.net/1893/31157-
dc.description.abstractCerebrovascular reactivity to carbon dioxide (CVR) is a common functional test to assess brain vascular health, though conflicting age and fitness effects have been reported. Studies have used different CO 2 stimulus durations to induce CVR and extracted data from different time points for analysis. Therefore, this study examined whether these differences alter CVR and explain conflicting findings. Eighteen healthy volunteers (24 5 years) inhaled CO ± 2 for four stimulus durations (1, 2, 4 and 5 min) of 5% CO 2 (in air) via the open-circuit Douglas bag method, in a randomized order. CVR data were derived from transcranial Doppler (TCD) measures of middle cerebral artery blood velocity (MCAv), with concurrent ventilatory sensitivity to the CO 2 stimulus (̇ V E,CO 2). Repeated measures ANOVAs compared CVR and ̇ V E,CO 2 measures between stimulus durations and steady-state time points. An effect of stimulus duration was observed (P = 0.002, í µí¼ 2 = = 0.140), with 1 min (P 0.010) and 2 min (P < 0.001) differing from 4 min, and 2 min differing from 5 min (P = 0.019) durations. ̇ V E CO , 2 sensitivity increased ∼3-fold from 1 min to 4 and 5 min durations (P < 0.001, í µí¼ 2 = 0.485). CVRs calculated from different steady-state time points within each stimulus duration were different (P < 0.001, í µí¼ 2 = = 0.454), specifically for 4 min (P 0.001) and 5 min (P P < 0.001), but not 2 min stimulus durations (= 0.273). These findings demonstrate that methodological differences alter the CVR measure.en_UK
dc.language.isoenen_UK
dc.publisherWileyen_UK
dc.relationBurley CV, Lucas RAI, Whittaker AC, Mullinger K & Lucas SJE (2020) The CO2 stimulus duration and steady-state time point used for data extraction alters the cerebrovascular reactivity outcome measure. Experimental Physiology, 105 (5), pp. 893-903. https://doi.org/10.1113/EP087883en_UK
dc.rightsThis item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. This is the peer reviewed version of the following article: Burley, CV, Lucas, RAI, Whittaker, AC, Mullinger, K, Lucas, SJE. The CO2 stimulus duration and steady-state time point used for data extraction alters the cerebrovascular reactivity outcome measure. Experimental Physiology. 2020; 105: 893– 903, which has been published in final form at https://doi.org/10.1113/EP087883. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archiving.en_UK
dc.rights.urihttps://storre.stir.ac.uk/STORREEndUserLicence.pdfen_UK
dc.subjectcerebrovascular reactivityen_UK
dc.subjectCO2 stimulusen_UK
dc.subjecttranscranial Doppleren_UK
dc.titleThe CO2 stimulus duration and steady-state time point used for data extraction alters the cerebrovascular reactivity outcome measureen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2021-02-22en_UK
dc.rights.embargoreason[accepted_article_feb_2020.pdf] Publisher requires embargo of 12 months after formal publication.en_UK
dc.identifier.doi10.1113/EP087883en_UK
dc.identifier.pmid32083357en_UK
dc.citation.jtitleExperimental Physiologyen_UK
dc.citation.issn1469-445Xen_UK
dc.citation.issn0958-0670en_UK
dc.citation.volume105en_UK
dc.citation.issue5en_UK
dc.citation.spage893en_UK
dc.citation.epage903en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.contributor.funderThe Physiological Societyen_UK
dc.contributor.funderUniversity of Birminghamen_UK
dc.author.emaila.c.whittaker@stir.ac.uken_UK
dc.citation.date21/02/2020en_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.identifier.isiWOS:000520521400001en_UK
dc.identifier.scopusid2-s2.0-85082021829en_UK
dc.identifier.wtid1617901en_UK
dc.contributor.orcid0000-0002-5461-0598en_UK
dc.date.accepted2020-02-19en_UK
dcterms.dateAccepted2020-02-19en_UK
dc.date.filedepositdate2020-05-14en_UK
dc.subject.tagStirling Physical Activity Research, Knowledge & Learning Exchange (SPARKLE)en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorBurley, Claire V|en_UK
local.rioxx.authorLucas, Rebekah A I|en_UK
local.rioxx.authorWhittaker, Anna C|0000-0002-5461-0598en_UK
local.rioxx.authorMullinger, Karen|en_UK
local.rioxx.authorLucas, Samuel J E|en_UK
local.rioxx.projectProject ID unknown|University of Birmingham|http://dx.doi.org/10.13039/501100000855en_UK
local.rioxx.projectProject ID unknown|The Physiological Society|en_UK
local.rioxx.freetoreaddate2021-02-22en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||2021-02-21en_UK
local.rioxx.licencehttps://storre.stir.ac.uk/STORREEndUserLicence.pdf|2021-02-22|en_UK
local.rioxx.filenameaccepted_article_feb_2020.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1469-445Xen_UK
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