Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/31137
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMortimer, Kevinen_UK
dc.contributor.authorLesosky, Maiaen_UK
dc.contributor.authorSemple, Seanen_UK
dc.contributor.authorMalava, Julitaen_UK
dc.contributor.authorKatundu, Cynthiaen_UK
dc.contributor.authorCrampin, Ameliaen_UK
dc.contributor.authorWang, Duolaoen_UK
dc.contributor.authorWeston, Williamen_UK
dc.contributor.authorPope, Danen_UK
dc.contributor.authorHavens, Deborahen_UK
dc.contributor.authorGordon, Stephen Ben_UK
dc.contributor.authorBalmes, Johnen_UK
dc.date.accessioned2020-05-13T00:08:03Z-
dc.date.available2020-05-13T00:08:03Z-
dc.date.issued2020-08en_UK
dc.identifier.urihttp://hdl.handle.net/1893/31137-
dc.description.abstractBackground Exposure to household air pollution is associated with an increased risk of pneumonia in children in low- and middle-income countries, however exposure-response data are limited and there are uncertainties around the extent to which biomass-fueled cookstoves can reduce these exposures. Research question What is the association between exposure to household air pollution and pneumonia in children under the age of 5 years in rural Malawi and what are the effects of a biomass-fueled cookstove intervention on personal exposure to household air pollution? Study design and methods We measured personal exposure to carbon monoxide (CO) [48 hours of continuous measurement and transcutaneous carboxyhemoglobin (COHb)] 6-monthly in children participating in a cluster-randomised controlled trial of a cleaner-burning biomass-fueled cookstove intervention to prevent pneumonia in children under the age of 5 years in rural Malawi – the Cooking And Pneumonia Study (CAPS). Exposure-response and multi-variable analyses were done. Results We recruited 1805 (928 intervention; 877 control) children (mean age 25.6 months, 50.6% female). We found no evidence of an association between exposure to CO (IRR=1.0 95% CI:0.967-1.014; p=0.53) or COHb (IRR=1.00 95% CI:0.993-1.003; p=0.41)) in children who experienced pneumonia versus those who did not. Median exposure to CO in the intervention and control groups was was 0.34 ppm (IQR 0.15-0.81) and 0.37 ppm (IQR 0.15-0.97), respectively. The group difference in means was 0.46 (95% CI:-0.95-0.012; p=0.06). Interpretation Exposure to CO in our population was low with no association seen between exposure to CO and pneumonia incidence and no effect of the CAPS intervention on these exposures. These findings suggest that CO may not be an appropriate measure of household air pollution exposure in settings like rural Malawi and that there is a need to develop ways to directly measure particulate matter exposures in young children instead.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationMortimer K, Lesosky M, Semple S, Malava J, Katundu C, Crampin A, Wang D, Weston W, Pope D, Havens D, Gordon SB & Balmes J (2020) Pneumonia and exposure to household air pollution in children under the age of 5 years in rural Malawi findings from the Cooking And Pneumonia Study. Chest, 158 (2), pp. 501-511. https://doi.org/10.1016/j.chest.2020.03.064en_UK
dc.rightsThis is an open access article distributed under the terms of the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You are not required to obtain permission to reuse this article.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectcookstoveen_UK
dc.subjecthousehold air pollutionen_UK
dc.subjectpneumoniaen_UK
dc.titlePneumonia and exposure to household air pollution in children under the age of 5 years in rural Malawi findings from the Cooking And Pneumonia Studyen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1016/j.chest.2020.03.064en_UK
dc.citation.jtitleChesten_UK
dc.citation.issn1931-3543en_UK
dc.citation.issn0012-3692en_UK
dc.citation.volume158en_UK
dc.citation.issue2en_UK
dc.citation.spage501en_UK
dc.citation.epage511en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderMedical Research Councilen_UK
dc.citation.date18/04/2020en_UK
dc.contributor.affiliationLiverpool John Moores Universityen_UK
dc.contributor.affiliationUniversity of Cape Townen_UK
dc.contributor.affiliationInstitute for Social Marketingen_UK
dc.contributor.affiliationLondon School of Hygiene and Tropical Medicineen_UK
dc.contributor.affiliationLondon School of Hygiene and Tropical Medicineen_UK
dc.contributor.affiliationLondon School of Hygiene and Tropical Medicineen_UK
dc.contributor.affiliationLiverpool School of Tropical Medicineen_UK
dc.contributor.affiliationLiverpool School of Tropical Medicineen_UK
dc.contributor.affiliationUniversity of Liverpoolen_UK
dc.contributor.affiliationLiverpool School of Tropical Medicineen_UK
dc.contributor.affiliationLiverpool School of Tropical Medicineen_UK
dc.contributor.affiliationUniversity of California, Berkeleyen_UK
dc.identifier.isiWOS:000570382500028en_UK
dc.identifier.scopusid2-s2.0-85088394845en_UK
dc.identifier.wtid1613475en_UK
dc.contributor.orcid0000-0002-0462-7295en_UK
dc.date.accepted2020-03-28en_UK
dc.date.filedepositdate2020-05-12en_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

Files in This Item:
File Description SizeFormat 
PIIS0012369220306929.pdfFulltext - Published Version702.54 kBAdobe PDFView/Open


This item is protected by original copyright



A file in this item is licensed under a Creative Commons License Creative Commons

Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.