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dc.contributor.authorWitard, Oliveren_UK
dc.contributor.authorTieland, Michaelen_UK
dc.contributor.authorBeelen, Milouen_UK
dc.contributor.authorTipton, Kevinen_UK
dc.contributor.authorvan Loon, Luc J Cen_UK
dc.contributor.authorCoopman, Reneen_UK
dc.description.abstractPurpose: We examined the impact of an acute bout of resistance-type exercise on mixed muscle protein synthesis in the fed state. Methods: After a standardized breakfast, 10 untrained males completed a single, unilateral lower-limb resistance-type exercise session. A primed, continuous infusion of L-[ring-13C6]phenylalanine was combined with muscle biopsy collection from both the exercised (Ex) and the nonexercised (NEx) leg to assess the impact of local muscle contractions on muscle protein synthesis rates after food intake. Western blotting with phosphospecific and pan antibodies was used to determine the phosphorylation status of AMP-activated kinase (AMPK), 4E-binding protein (4E-BP1), mammalian target of rapamycin (mTOR), and p70 ribosomal protein S6 kinase (S6K1). Results: Muscle protein synthesis rates were approximately 20% higher in Ex compared with NEx (0.098% T 0.005% vs 0.083% T 0.002%Ihj1, respectively, P G 0.01). In the fed state, resistance-type exercise did not elevate AMPK phosphorylation. However, the phosphorylation status of 4E-BP1 was approximately 20% lower after cessation of exercise in Ex compared with NEx (P G 0.05). Conversely, 4E-BP1 phosphorylation was significantly higher in Ex compared with NEx after 6 h of recovery (P G 0.05) with no changes in mTOR phosphorylation. S6 phosphorylation was greater in Ex versus NEx after cessation of exercise (P G 0.05), although S6K1 phosphorylation at T389 was not up-regulated (P 9 0.05). Conclusion: We conclude that resistance-type exercise performed in a fed state further elevates postprandial muscle protein synthesis rates, which is accompanied by an increase in S6 and 4E-BP1 phosphorylation stateen_UK
dc.publisherLippincott Williams & Wilkins / American College of Sports Medicine (ACSM)en_UK
dc.relationWitard O, Tieland M, Beelen M, Tipton K, van Loon LJC & Coopman R (2009) Resistance Exercise Increases Postprandial Muscle Protein Synthesis in Humans. Medicine and Science in Sports and Exercise, 41 (1), pp. 144-154.
dc.rightsCopyright 2008 by the American College of Sports Medicine; The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author; you can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectSkeletal muscleen_UK
dc.subjectFood intakeen_UK
dc.subjectExercise Physiological aspectsen_UK
dc.subjectMusculoskeletal system Physiologyen_UK
dc.titleResistance Exercise Increases Postprandial Muscle Protein Synthesis in Humansen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[Witard 09 postprandial ex FSR MSSE.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleMedicine and Science in Sports and Exerciseen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Maastrichten_UK
dc.contributor.affiliationUniversity of Maastrichten_UK
dc.contributor.affiliationUniversity of Maastrichten_UK
dc.contributor.affiliationUniversity of Maastrichten_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorWitard, Oliver|0000-0002-5875-8397en_UK
local.rioxx.authorTieland, Michael|en_UK
local.rioxx.authorBeelen, Milou|en_UK
local.rioxx.authorTipton, Kevin|0000-0002-6545-8122en_UK
local.rioxx.authorvan Loon, Luc J C|en_UK
local.rioxx.authorCoopman, Rene|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenameWitard 09 postprandial ex FSR MSSE.pdfen_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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