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dc.contributor.authorTipton, Kevinen_UK
dc.contributor.authorElliott, Tabatha Aen_UK
dc.contributor.authorFerrando, Arny Aen_UK
dc.contributor.authorAarsland, Asle Aen_UK
dc.contributor.authorWolfe, Robert Ren_UK
dc.description.abstractLeucine is known to stimulate muscle protein synthesis and anabolism. However, evidence for the efficacy of additional leucine to enhance the response of muscle anabolism to resistance exercise and protein ingestion is unclear. Thus, we investigated the response of net muscle protein balance to ingestion of additional leucine with protein in association with resistance exercise. Two groups of untrained subjects performed an intense bout of leg resistance exercise following ingestion of 1 of 2 drinks: flavored water (PL); or 16.6 g of whey protein + 3.4 g of leucine (W+L). Arteriovenous amino acid balance across the leg was measured to assess the anabolic response of muscle in each group. Arterial amino acid concentrations increased in response to ingestion of W+L. Amino acid concentrations peaked between 60 and 120 min after ingestion, and then declined to baseline values. Valine concentration decreased to levels significantly lower than baseline. Net balance of leucine, threonine, and phenylalanine did not change following PL ingestion, but increased and remained elevated above baseline for 90–120 min following W+L ingestion. Leucine (138 ± 37 and –23 ± 23 mg), phenylalanine (58 ± 28 and –38 ± 14 mg), and threonine (138 ± 37 and –23 ± 23 mg) uptake was greater for W+L than for PL over the 5.5 h following drink ingestion. Our results indicate that the whey protein plus leucine in healthy young volunteers results in an anabolic response in muscle that is not greater than the previously reported response to whey protein alone.en_UK
dc.publisherNRC Research Press / Canadian Science Publishingen_UK
dc.relationTipton K, Elliott TA, Ferrando AA, Aarsland AA & Wolfe RR (2009) Stimulation of muscle anabolism by resistance exercise and ingestion of leucine plus protein. Applied Physiology, Nutrition, and Metabolism, 34 (2), pp. 151-161.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author; you can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectarteriovenous balanceen_UK
dc.subjectnet muscle protein synthesisen_UK
dc.subjectLeucine aminopeptidaseen_UK
dc.subjectExercise Physiological aspectsen_UK
dc.titleStimulation of muscle anabolism by resistance exercise and ingestion of leucine plus proteinen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[tipton 09 leu prot msc anabolism APNM.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleApplied Physiology, Nutrition, and Metabolismen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Texas Medical Branchen_UK
dc.contributor.affiliationUniversity of Texasen_UK
dc.contributor.affiliationUniversity of Texas Medical Branchen_UK
dc.contributor.affiliationUniversity of Texasen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorTipton, Kevin|0000-0002-6545-8122en_UK
local.rioxx.authorElliott, Tabatha A|en_UK
local.rioxx.authorFerrando, Arny A|en_UK
local.rioxx.authorAarsland, Asle A|en_UK
local.rioxx.authorWolfe, Robert R|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenametipton 09 leu prot msc anabolism APNM.pdfen_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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