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Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: The Smoking Cessation in Pregnancy Incentives Trial (CPIT): study protocol for a phase III randomised controlled trial
Author(s): Sinclair, Lesley
McFadden, Margaret
Tilbrook, Helen
Mitchell, Alex
Keding, Ada
Watson, Judith
Bauld, Linda
Kee, Frank
Torgerson, David
McKell, Jennifer
Hoddinott, Pat
Harris, Fiona M
Uny, Isabelle
Ussher, Michael
Tappin, David
Keywords: Intervention
Randomised controlled trial
Maternal and child health
Smoking cessation
Financial incentives
Issue Date: 14-Feb-2020
Citation: Sinclair L, McFadden M, Tilbrook H, Mitchell A, Keding A, Watson J, Bauld L, Kee F, Torgerson D, McKell J, Hoddinott P, Harris FM, Uny I, Ussher M & Tappin D (2020) The Smoking Cessation in Pregnancy Incentives Trial (CPIT): study protocol for a phase III randomised controlled trial. Trials, 21 (1), Art. No.: 183.
Abstract: Background Eighty per cent of UK women have at least one baby, making pregnancy an opportunity to help women stop smoking before their health is irreparably compromised. Smoking cessation during pregnancy helps protect infants from miscarriage, still birth, low birth weight, asthma, attention deficit disorder and adult cardiovascular disease. UK national guidelines highlight lack of evidence for effectiveness of financial incentives to help pregnant smokers quit. This includes a research recommendation: within a UK context, are incentives an acceptable, effective and cost-effective way to help pregnant women who smoke to quit? Methods The Cessation in Pregnancy Incentives Trial (CPIT) III is a pragmatic, 42-month, multi-centre, parallel-group, individually randomised controlled superiority trial of the effect on smoking status of adding to usual Stop Smoking Services (SSS) support, the offer of up to £400 of financial voucher incentives, compared with usual support alone, to quit smoking during pregnancy. Participants (n = 940) are pregnant smokers (age > 16 years,
DOI Link: 10.1186/s13063-019-4042-8
Rights: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Notes: Additional co-authors: Catherine Hewitt, Kathleen Boyd, Nicola McMeekin & for the CPIT III local research teams
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