Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/30626
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dc.contributor.authorForbes, Gordonen_UK
dc.contributor.authorLoudon, Kirstyen_UK
dc.contributor.authorClinch, Meganen_UK
dc.contributor.authorTaylor, Stephanie J Cen_UK
dc.contributor.authorTreweek, Shaunen_UK
dc.contributor.authorEldridge, Sandraen_UK
dc.date.accessioned2020-01-15T01:03:12Z-
dc.date.available2020-01-15T01:03:12Z-
dc.date.issued2019-12en_UK
dc.identifier.other711en_UK
dc.identifier.urihttp://hdl.handle.net/1893/30626-
dc.description.abstractBackground Pragmatic trials have been suggested as a way to improve the relevance of clinical trial results to practice. PRECIS-2 (Pragmatic Explanatory Continuum Indicator Summary-2) is a trial design tool which considers how pragmatic a trial is across a number of domains. It is not known whether a pragmatic approach to all PRECIS-2 domains leads to results being more relevant to primary care. The aim of this study was to investigate the views of people with influence on primary care practice towards the design of randomised trials, pragmatic approaches to trial design, and the PRECIS-2 domains. Methods We carried out semi-structured interviews with people who influence practice in primary care in the UK. A thematic analysis was undertaken using the framework approach. Results We conducted individual or small group interviews involving an elite sample of 17 individuals. We found that an exclusively pragmatic approach to randomised trials may not always make the results of trials more applicable to primary care. For example, it may be better to have less flexibility in the way interventions are delivered in randomised trials than in practice. In addition, an appropriate balance needs to be struck when thinking about levels of resourcing and the intensity of steps needed to improve adherence in a trial. Across other aspects of a trial’s design, for example the population and trial setting, a pragmatic approach was viewed as more appropriate. Conclusions To maximize the relevance of research directed at primary care, trials should be conducted with the same populations and settings that are found in primary care. Across other aspects of trials it is not always necessary to match the conditions found in practice.en_UK
dc.language.isoenen_UK
dc.publisherBMCen_UK
dc.relationForbes G, Loudon K, Clinch M, Taylor SJC, Treweek S & Eldridge S (2019) Improving the relevance of randomised trials to primary care: a qualitative study investigating views towards pragmatic trials and the PRECIS-2 tool. Trials, 20 (1), Art. No.: 711. https://doi.org/10.1186/s13063-019-3812-7en_UK
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectPragmatic clinical trialen_UK
dc.subjectPrimary health careen_UK
dc.subjectRandomised controlled trialen_UK
dc.subjectPRECIS-2en_UK
dc.titleImproving the relevance of randomised trials to primary care: a qualitative study investigating views towards pragmatic trials and the PRECIS-2 toolen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1186/s13063-019-3812-7en_UK
dc.identifier.pmid31829266en_UK
dc.citation.jtitleTrialsen_UK
dc.citation.issn1745-6215en_UK
dc.citation.volume20en_UK
dc.citation.issue1en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderQueen Mary University of Londonen_UK
dc.citation.date11/12/2019en_UK
dc.contributor.affiliationKing's College Londonen_UK
dc.contributor.affiliationNMAHPen_UK
dc.contributor.affiliationQueen Mary, University of Londonen_UK
dc.contributor.affiliationQueen Mary, University of Londonen_UK
dc.contributor.affiliationUniversity of Aberdeenen_UK
dc.contributor.affiliationQueen Mary, University of Londonen_UK
dc.identifier.isiWOS:000506885800006en_UK
dc.identifier.scopusid2-s2.0-85076375020en_UK
dc.identifier.wtid1499400en_UK
dc.contributor.orcid0000-0002-4449-6226en_UK
dc.date.accepted2019-10-22en_UK
dc.date.filedepositdate2020-01-13en_UK
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