Please use this identifier to cite or link to this item:
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Depressive symptoms in hip fracture patients are associated with reduced monocyte superoxide production
Author(s): Duggal, Niharika Arora
Beswetherick, Amy
Upton, Jane
Hampson, Peter
Phillips, Anna C.
Lord, Janet M.
Keywords: Ageing
Depressive symptoms
Hip fracture
Monocyte function
Issue Date: Jun-2014
Citation: Duggal NA, Beswetherick A, Upton J, Hampson P, Phillips AC & Lord JM (2014) Depressive symptoms in hip fracture patients are associated with reduced monocyte superoxide production. Experimental Gerontology, 54, pp. 27-34.
Abstract: Ageing is accompanied by reduced functioning of the immune system, termed immunesenescence which is associated with increased risk of infection and mortality. However the immune system does not operate in isolation and can be modified by many environmental factors, including stress. In this study we determined whether physical stress (hip fracture) and psychological distress (depressive symptoms) had additive effects upon the aged immune system, specifically on monocyte numbers and function. We assessed immune function in 101 hip fracture patients (81 female) 6 weeks and 6 months after injury and 43 healthy age matched controls (28 females). Thirty-eight of the hip fracture group were found to be depressed at the 6 week sampling. No differences in peripheral monocyte count, distribution of monocyte subsets or TNFα secretion were observed between hip fracture patients and healthy controls. However we observed significantly reduced superoxide production in response to Escherichia coli in the monocytes of hip fracture patients who developed depressive symptoms compared with non-depressed hip fracture patients (p = 0.002) or healthy controls (p = 0.008) 6 weeks after the fracture which remained decreased 6 months following injury. In previous studies we have shown an effect of depression on neutrophil superoxide generation in hip fracture patients, suggesting a particular susceptibility of this aspect of immune cell function to psychological stress.
DOI Link: 10.1016/j.exger.2014.01.028
Rights: This article is available under the terms of the Creative Commons Attribution License (CC BY - You may distribute and copy the article, create extracts, abstracts, and other revised versions, adaptations or derivative works of or from an article (such as a translation), to include in a collective work (such as an anthology), to text or data mine the article, including for commercial purposes without permission from Elsevier. The original work must always be appropriately credited.
Licence URL(s):

Files in This Item:
File Description SizeFormat 
1-s2.0-S0531556514000473-main.pdfFulltext - Published Version746.77 kBAdobe PDFView/Open

This item is protected by original copyright

A file in this item is licensed under a Creative Commons License Creative Commons

Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact providing details and we will remove the Work from public display in STORRE and investigate your claim.