Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/30218
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDuggal, Niharika Aroraen_UK
dc.contributor.authorUpton, Janeen_UK
dc.contributor.authorPhillips, Anna Cen_UK
dc.contributor.authorLord, Janet Men_UK
dc.date.accessioned2019-10-02T00:04:23Z-
dc.date.available2019-10-02T00:04:23Z-
dc.date.issued2016-02en_UK
dc.identifier.urihttp://hdl.handle.net/1893/30218-
dc.description.abstractHip fracture is a common physical trauma in older adults that is also associated with a high incidence of new onset depression. The immune system declines with age and is also compromised by physical and psychological stress. This study examined whether hip fracture and depressive symptoms had additive effects upon the aged immune system that might contribute to poor health outcomes after hip fracture. We assessed the frequency of regulatory T cells, Tregs (CD4+ CD25+ Foxp3+) and IL10 production by CD4 T cells, and the frequency and IL10 production by regulatory B cells, Bregs (CD19+ CD24hi CD38hi) in 101 hip fracture patients (81 female) 6 weeks after injury and 43 healthy age-matched controls (28 female). 38 hip fracture patients (37 %) developed depressive symptoms. Hip fracture did not have an effect on circulating Tregs frequency but a significant reduction in the frequency of Bregs was observed in patients who developed depression compared with non-depressed patients (p = 0.001) or healthy controls (p < 0.001). Bregs also showed a significant decline in IL10 production in depressed hip fracture patients compared with controls (p = 0.04) and non-depressed patients (p = 0.01). In contrast, there was an increase in IL10 production by CD4 T cells in hip fracture patients with new onset depression compared to hip fracture patients without depression (p = .04) and healthy controls (p = .02). We conclude that the reduced immunity associated with new onset depression post hip fracture could include a contribution by heightened Tregs function.en_UK
dc.language.isoenen_UK
dc.publisherSpringer Natureen_UK
dc.relationDuggal NA, Upton J, Phillips AC & Lord JM (2016) Development of depressive symptoms post hip fracture is associated with altered immunosuppressive phenotype in regulatory T and B lymphocytes. Biogerontology, 17 (1), pp. 229-239. https://doi.org/10.1007/s10522-015-9587-7en_UK
dc.rights© The Author(s) 2015 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectHip fractureen_UK
dc.subjectDepressionen_UK
dc.subjectRegulatory T cellen_UK
dc.subjectRegulatory B cellen_UK
dc.subjectStressen_UK
dc.subjectImmunesenescenceen_UK
dc.titleDevelopment of depressive symptoms post hip fracture is associated with altered immunosuppressive phenotype in regulatory T and B lymphocytesen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1007/s10522-015-9587-7en_UK
dc.identifier.pmid26112234en_UK
dc.citation.jtitleBiogerontologyen_UK
dc.citation.issn1573-6768en_UK
dc.citation.issn1389-5729en_UK
dc.citation.volume17en_UK
dc.citation.issue1en_UK
dc.citation.spage229en_UK
dc.citation.epage239en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderEconomic and Social Research Councilen_UK
dc.citation.date26/06/2015en_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.identifier.isiWOS:000368711200018en_UK
dc.identifier.scopusid2-s2.0-84955333776en_UK
dc.identifier.wtid1414396en_UK
dc.contributor.orcid0000-0002-5461-0598en_UK
dc.date.accepted2015-06-13en_UK
dc.date.filedepositdate2019-07-19en_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

Files in This Item:
File Description SizeFormat 
Duggal et al_Biogerontol for OA.pdfFulltext - Published Version608.05 kBAdobe PDFView/Open


This item is protected by original copyright



A file in this item is licensed under a Creative Commons License Creative Commons

Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.