Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/30178
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dc.contributor.authorHeaney, Jennifer L Jen_UK
dc.contributor.authorPhillips, Anna Cen_UK
dc.contributor.authorCarroll, Douglasen_UK
dc.contributor.authorDrayson, Mark Ten_UK
dc.date.accessioned2019-09-26T00:04:22Z-
dc.date.available2019-09-26T00:04:22Z-
dc.date.issued2015-12en_UK
dc.identifier.urihttp://hdl.handle.net/1893/30178-
dc.description.abstractBackground. Bacterial infections in the elderly are common and associated with high morbidity and mortality, with pneumonia the second commonest cause of death. Reductions in antibodies against specific bacterial antigens in saliva and serum could contribute to infection risk in older adults, although they have yet to be examined in relation to age. Method. IgG, IgA and IgM antibody levels in paired saliva and serum samples were measured against 12 pneumococcal, 4 meningococcal and haemophilus polysaccharide antigens and diphtheria and tetanus toxoids in healthy younger ( n = 28, 21–34 years) and older ( n = 44, 60–80 years) adults. Results. Older adults had lower antibody concentrations in saliva than young adults, with the most striking differences observed for salivary antibody secretion rates. In serum, older adults registered lower concentrations for only a minority of antibodies. Young adults who had previously received a polysaccharide pneumococcal vaccination (PPV23) had higher levels of anti-pneumococcal antibodies in serum and in saliva. Only minor differences were observed in antibody levels between older adults who had/had not received PPV23, and there was no evidence of memory in saliva. Conclusions. Age differences were much greater in salivary antibodies than in serum; older adults had reduced salivary secretion rates of antibodies across bacterial antigens. This decline in local immunity may contribute to increased infection risk in the elderly. The poor memory from pneumococcal vaccination in serum and saliva suggests that PPV23 may be ineffective in older adults for both systemic and local protection.en_UK
dc.language.isoenen_UK
dc.publisherOxford University Press (OUP)en_UK
dc.relationHeaney JLJ, Phillips AC, Carroll D & Drayson MT (2015) Salivary Functional Antibody Secretion Is Reduced in Older Adults: A Potential Mechanism of Increased Susceptibility to Bacterial Infection in the Elderly. The Journals of Gerontology, Series A, 70 (12), pp. 1578-1585. https://doi.org/10.1093/gerona/glv085en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectimmune functionen_UK
dc.subjectinfectionen_UK
dc.subjectbacteriaen_UK
dc.titleSalivary Functional Antibody Secretion Is Reduced in Older Adults: A Potential Mechanism of Increased Susceptibility to Bacterial Infection in the Elderlyen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31en_UK
dc.rights.embargoreason[J Gerontol A Biol Sci Med Sci-2015-Heaney-gerona_glv085.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1093/gerona/glv085en_UK
dc.identifier.pmid26328602en_UK
dc.citation.jtitleJournals of Gerontology, Series Aen_UK
dc.citation.issn1758-535Xen_UK
dc.citation.issn1079-5006en_UK
dc.citation.volume70en_UK
dc.citation.issue12en_UK
dc.citation.spage1578en_UK
dc.citation.epage1585en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderUniversity of Birminghamen_UK
dc.author.emaila.c.whittaker@stir.ac.uken_UK
dc.citation.date31/08/2015en_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.identifier.isiWOS:000368364100016en_UK
dc.identifier.scopusid2-s2.0-84957793666en_UK
dc.identifier.wtid1420282en_UK
dc.contributor.orcid0000-0002-5461-0598en_UK
dc.date.accepted2015-05-18en_UK
dc.date.filedepositdate2019-07-30en_UK
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