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http://hdl.handle.net/1893/30161| Appears in Collections: | Faculty of Health Sciences and Sport Journal Articles |
| Peer Review Status: | Refereed |
| Title: | NK cell immunesenescence is increased by psychological but not physical stress in older adults associated with raised cortisol and reduced perforin expression |
| Author(s): | Duggal, Niharika Arora Upton, Jane Phillips, Anna C Hampson, Peter Lord, Janet M |
| Contact Email: | a.c.whittaker@stir.ac.uk |
| Keywords: | NK cell Stress Immunesenescence Cortisol |
| Issue Date: | 7-Feb-2015 |
| Date Deposited: | 30-Jul-2019 |
| Citation: | Duggal NA, Upton J, Phillips AC, Hampson P & Lord JM (2015) NK cell immunesenescence is increased by psychological but not physical stress in older adults associated with raised cortisol and reduced perforin expression. AGE, 37 (1), Art. No.: 11. https://doi.org/10.1007/s11357-015-9748-2 |
| Abstract: | NK cell cytotoxicity (NKCC) reduces with age and this has been associated previously with increased mortality. The immune response is also modulated by stress, and here, we assessed the effect of the physical stress of hip fracture and the psychological stress of depression on NKCC in an aged immune system. NKCC was assessed in 101 hip fracture patients (81 female) 6 weeks and 6 months after injury and in 50 healthy age-matched controls (28 female). Thirty-eight patients were depressed at 6 weeks post-injury, and NKCC was reduced in patients who developed depression compared with non-depressed hip fracture patients (p = 0.004) or controls (p |
| DOI Link: | 10.1007/s11357-015-9748-2 |
| Rights: | Copyright The Author(s) 2015. This article is published with open access at Springerlink.com This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| Licence URL(s): | http://creativecommons.org/licenses/by/4.0/ |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Hip dep NK cells.pdf | Fulltext - Published Version | 603.55 kB | Adobe PDF | View/Open |
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