Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/30161
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: NK cell immunesenescence is increased by psychological but not physical stress in older adults associated with raised cortisol and reduced perforin expression
Author(s): Duggal, Niharika Arora
Upton, Jane
Phillips, Anna C
Hampson, Peter
Lord, Janet M
Contact Email: a.c.whittaker@stir.ac.uk
Keywords: NK cell
Stress
Immunesenescence
Cortisol
Issue Date: 7-Feb-2015
Citation: Duggal NA, Upton J, Phillips AC, Hampson P & Lord JM (2015) NK cell immunesenescence is increased by psychological but not physical stress in older adults associated with raised cortisol and reduced perforin expression. AGE, 37 (1), Art. No.: 11. https://doi.org/10.1007/s11357-015-9748-2
Abstract: NK cell cytotoxicity (NKCC) reduces with age and this has been associated previously with increased mortality. The immune response is also modulated by stress, and here, we assessed the effect of the physical stress of hip fracture and the psychological stress of depression on NKCC in an aged immune system. NKCC was assessed in 101 hip fracture patients (81 female) 6 weeks and 6 months after injury and in 50 healthy age-matched controls (28 female). Thirty-eight patients were depressed at 6 weeks post-injury, and NKCC was reduced in patients who developed depression compared with non-depressed hip fracture patients (p = 0.004) or controls (p 
DOI Link: 10.1007/s11357-015-9748-2
Rights: Copyright The Author(s) 2015. This article is published with open access at Springerlink.com This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Licence URL(s): http://creativecommons.org/licenses/by/4.0/

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