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Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: A statistical and biological response to an informatics appraisal of healthy aging gene signatures
Author(s): Timmons, James A
Gallagher, Iain J
Sood, Sanjana
Phillips, Bethan
Crossland, Hannah
Howard, Robert
Kraus, William E
Atherton, Philip J
Issue Date: 2-Aug-2019
Citation: Timmons JA, Gallagher IJ, Sood S, Phillips B, Crossland H, Howard R, Kraus WE & Atherton PJ (2019) A statistical and biological response to an informatics appraisal of healthy aging gene signatures. Genome Biology, 20 (1), Art. No.: 152.
Abstract: Jacob and Speed did not identify even a single example of a ‘150-gene-set’ that was statistically significant at classifying Alzheimer’s disease (AD) samples, or age in independent studies. We attempt to clarify the various misunderstandings.
DOI Link: 10.1186/s13059-019-1734-z
Rights: © 2019 BioMed Central Ltd unless otherwise stated. Part of Springer Nature. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
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