Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/29911
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dc.contributor.authorHeaney, Jennifer L Jen_UK
dc.contributor.authorPhillips, Anna Cen_UK
dc.contributor.authorDrayson, Mark Ten_UK
dc.contributor.authorCampbell, John Pen_UK
dc.date.accessioned2019-07-24T00:02:46Z-
dc.date.available2019-07-24T00:02:46Z-
dc.date.issued2016-05en_UK
dc.identifier.urihttp://hdl.handle.net/1893/29911-
dc.description.abstractTraditionally, free light chains (FLCs) are used as key serum biomarkers in the diagnosis and monitoring of plasma cell malignancies, but polyclonal FLCs can also be used as an accurate real-time indicator of immune-activation and inflammation. The primary aim of the present study was to assess the effects of exercise training status on serum FLCs in older adults, and secondly, to examine if training status moderated serum FLC responses to acute exercise. Kappa and lambda serum FLC levels were measured in 45 healthy older adults (aged ≥ 60 years) who were either sedentary, physically active or endurance trained. FLCs were measured at baseline and in response to an acute bout of submaximal exercise. The endurance trained group had significantly lower levels of kappa and lambda serum FLCs compared with physically active or sedentary elderly adults; these effects were independent of age, BMI and renal function. There was no significant difference in whole immunoglobulins between groups. Exercise training status had no effect on serum FLC responses to acute exercise, which were marginal. In conclusion, endurance training was associated with lower FLC levels compared with less physically active individuals. These findings suggest that long-term endurance training may be beneficial in reducing basal inflammation in older adults as well as elevated FLCs present in inflammatory and autoimmune conditions, often associated with ageing. FLCs may serve as a useful biomarker for monitoring the efficacy of exercise intervention studies in healthy and clinical populations.en_UK
dc.language.isoenen_UK
dc.publisherElsevier BVen_UK
dc.relationHeaney JLJ, Phillips AC, Drayson MT & Campbell JP (2016) Serum free light chains are reduced in endurance trained older adults: Evidence that exercise training may reduce basal inflammation in older adults. Experimental Gerontology, 77, pp. 69-75. https://doi.org/10.1016/j.exger.2016.02.011en_UK
dc.rightsAccepted refereed manuscript of: Heaney JLJ, Phillips AC, Drayson MT & Campbell JP (2016) Serum free light chains are reduced in endurance trained older adults: Evidence that exercise training may reduce basal inflammation in older adults. Experimental Gerontology, 77, pp. 69-75. DOI: https://doi.org/10.1016/j.exger.2016.02.011 © 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/en_UK
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_UK
dc.subjectFree light chainen_UK
dc.subjectSerumen_UK
dc.subjectImmunoglobulinen_UK
dc.subjectExerciseen_UK
dc.subjectInflammationen_UK
dc.subjectOlder adultsen_UK
dc.titleSerum free light chains are reduced in endurance trained older adults: Evidence that exercise training may reduce basal inflammation in older adultsen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2019-07-23en_UK
dc.identifier.doi10.1016/j.exger.2016.02.011en_UK
dc.identifier.pmid26921802en_UK
dc.citation.jtitleExperimental Gerontologyen_UK
dc.citation.issn0531-5565en_UK
dc.citation.volume77en_UK
dc.citation.spage69en_UK
dc.citation.epage75en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.contributor.funderUniversity of Birminghamen_UK
dc.author.emaila.c.whittaker@stir.ac.uken_UK
dc.citation.date26/02/2016en_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.identifier.isiWOS:000372815800010en_UK
dc.identifier.scopusid2-s2.0-84959277868en_UK
dc.identifier.wtid1414371en_UK
dc.contributor.orcid0000-0002-5461-0598en_UK
dc.date.accepted2016-02-22en_UK
dc.date.filedepositdate2019-07-19en_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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