Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/29889
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Cardiovascular reactivity patterns and pathways to hypertension: a multivariate cluster analysis
Author(s): Brindle, Ryan C
Ginty, Annie T
Jones, Alexander
Phillips, Anna C
Roseboom, Tessa J
Carroll, Douglas
Painter, Rebecca C
de Rooij, Susanne R
Contact Email: a.c.whittaker@stir.ac.uk
Keywords: Psychological Stress
Multivariate Cluster Analysis
Hypertension
Blood Pressure
Heart Rate
Body Mass Index
Issue Date: Dec-2016
Citation: Brindle RC, Ginty AT, Jones A, Phillips AC, Roseboom TJ, Carroll D, Painter RC & de Rooij SR (2016) Cardiovascular reactivity patterns and pathways to hypertension: a multivariate cluster analysis. Journal of Human Hypertension, 30 (12), pp. 755-760. https://doi.org/10.1038/jhh.2016.35
Abstract: Substantial evidence links exaggerated mental stress induced blood pressure reactivity to future hypertension, but the results for heart rate reactivity are less clear. For this reason multivariate cluster analysis was carried out to examine the relationship between heart rate and blood pressure reactivity patterns and hypertension in a large prospective cohort (age range 55–60 years). Four clusters emerged with statistically different systolic and diastolic blood pressure and heart rate reactivity patterns. Cluster 1 was characterised by a relatively exaggerated blood pressure and heart rate response while the blood pressure and heart rate responses of cluster 2 were relatively modest and in line with the sample mean. Cluster 3 was characterised by blunted cardiovascular stress reactivity across all variables and cluster 4, by an exaggerated blood pressure response and modest heart rate response. Membership to cluster 4 conferred an increased risk of hypertension at 5-year follow-up (hazard ratio=2.98 (95% CI: 1.50–5.90), P
DOI Link: 10.1038/jhh.2016.35
Rights: Please cite as: Brindle RC, Ginty AT, Jones A, Phillips AC, Roseboom TJ, Carroll D, Painter RC & de Rooij SR (2016) Cardiovascular reactivity patterns and pathways to hypertension: a multivariate cluster analysis. Journal of Human Hypertension, 30 (12), pp. 755-760. https://doi.org/10.1038/jhh.2016.35. Users may view, print, copy, download and text and data-mine the content, for the purposes of academic research, subject always to the full conditions of use. Any further use is subject to permission from Springer Nature. The conditions of use are not intended to override, should any national law grant further rights to any user.

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