Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/29868
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dc.contributor.authorBrindle, Ryan Cen_UK
dc.contributor.authorGinty, Annie Ten_UK
dc.contributor.authorWhittaker, Anna Cen_UK
dc.contributor.authorCarroll, Douglasen_UK
dc.contributor.authorLucas, Samuel J Een_UK
dc.date.accessioned2019-07-17T00:01:00Z-
dc.date.available2019-07-17T00:01:00Z-
dc.date.issued2018-12en_UK
dc.identifier.othere13265en_UK
dc.identifier.urihttp://hdl.handle.net/1893/29868-
dc.description.abstractRecent evidence indicates that cerebral autoregulation (CA) might be more pressure passive than previously thought. That is, cerebral blood flow, traditionally thought to be regulated independently of prevailing mean arterial pressure (MAP), might fluctuate, to some extent, as a function of MAP. However, due to limitations associated with experimental usage of pharmaceuticals to manipulate MAP and inconsistent control of arterial carbon dioxide, questions remain regarding the MAP‐cerebral blood flow relationship, especially during typical daily activities that alter MAP. Therefore, the current study aimed to assess CA using a nonpharmacological acute psychological stress task to augment MAP, while at the same time controlling for end‐tidal carbon dioxide (PETCO2). Twenty‐five healthy young adults completed a stressful task while continuous measures of MAP, middle cerebral artery blood flow velocity (MCAv), and PETCO2 were recorded. Slope values obtained from hierarchical linear regression were used to assess the strength of the MAP‐MCAv relationship and control for PETCO2. The stress task significantly increased MAP (p < 0.001) and MCAv (p < 0.001), and decreased PETCO2 (p = 0.05). For every 10 mmHg task‐induced increase in MAP, MCAv increased by ≈3.5%; task‐induced changes in PETCO2 did not appreciably change the MAP‐MCAv relationship. Greater task‐induced MAP responses were significantly related to decreased MAP‐MCAv slope values, consistent with CA. These data support the hypothesis that CA is more pressure passive than previously thought and provide initial evidence indicating that a pressure‐passive MAP‐MCAv relationship may play a role in the observed associations between MAP stress responses, stroke, and cerebrovascular disease.en_UK
dc.language.isoenen_UK
dc.publisherWileyen_UK
dc.relationBrindle RC, Ginty AT, Whittaker AC, Carroll D & Lucas SJE (2018) Assessment of the cerebral pressure-flow relationship using psychological stress to manipulate blood pressure. Psychophysiology, 55 (12), Art. No.: e13265. https://doi.org/10.1111/psyp.13265en_UK
dc.rights[Brindle_et_al-2018-Psychophysiology.pdf] The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights[Ryan_Brindle_et_al_Assessment_of_the_cerebral_pressure_Psychophysiology_2018.pdf] This is the peer reviewed version of the following article: Brindle, RC, Ginty, AT, Whittaker, AC, Carroll, D, Lucas, SJE. Assessment of the cerebral pressure‐flow relationship using psychological stress to manipulate blood pressure. Psychophysiology. 2018; 55:e13265, which has been published in final form at https://doi.org/10.1111/psyp.13265. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archiving.en_UK
dc.rights.urihttps://storre.stir.ac.uk/STORREEndUserLicence.pdfen_UK
dc.subjectblood pressureen_UK
dc.subjectcerebral blood flowen_UK
dc.subjectstressen_UK
dc.titleAssessment of the cerebral pressure-flow relationship using psychological stress to manipulate blood pressureen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2019-07-31en_UK
dc.rights.embargoreason[Brindle_et_al-2018-Psychophysiology.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1111/psyp.13265en_UK
dc.identifier.pmid30059151en_UK
dc.citation.jtitlePsychophysiologyen_UK
dc.citation.issn1469-8986en_UK
dc.citation.issn0048-5772en_UK
dc.citation.volume55en_UK
dc.citation.issue12en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderUniversity of Birminghamen_UK
dc.contributor.funderUniversity of Birminghamen_UK
dc.author.emaila.c.whittaker@stir.ac.uken_UK
dc.citation.date30/07/2018en_UK
dc.contributor.affiliationUniversity of Pittsburghen_UK
dc.contributor.affiliationBaylor Universityen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.identifier.isiWOS:000451425600005en_UK
dc.identifier.scopusid2-s2.0-85057491192en_UK
dc.identifier.wtid1410957en_UK
dc.contributor.orcid0000-0002-5461-0598en_UK
dc.date.accepted2018-06-11en_UK
dc.date.filedepositdate2019-07-31en_UK
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