Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/29865
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Effects on Cardiovascular Risk Scores and Vascular Age After Aerobic Exercise and Nutritional Intervention in Sedentary and Overweight/Obese Adults with Primary Hypertension: The EXERDIET-HTA Randomized Trial Study
Author(s): Gorostegi-Anduaga, Ilargi
Maldonado-Martín, Sara
MartinezAguirre-Betolaza, Aitor
Corres, Pablo
Romaratezabala, Estíbaliz
Whittaker, Anna C
Francisco-Terreros, Silvia
Pérez-Asenjo, Javier
Contact Email: a.c.whittaker@stir.ac.uk
Keywords: Lifestyle intervention
Gender
Systolic blood pressure
Vascular age
Cardiovascular risk score
Obesity
Overweight
Issue Date: Dec-2018
Citation: Gorostegi-Anduaga I, Maldonado-Martín S, MartinezAguirre-Betolaza A, Corres P, Romaratezabala E, Whittaker AC, Francisco-Terreros S & Pérez-Asenjo J (2018) Effects on Cardiovascular Risk Scores and Vascular Age After Aerobic Exercise and Nutritional Intervention in Sedentary and Overweight/Obese Adults with Primary Hypertension: The EXERDIET-HTA Randomized Trial Study. High Blood Pressure & Cardiovascular Prevention, 25 (4), pp. 361-368. https://doi.org/10.1007/s40292-018-0281-0
Abstract: Introduction The EXERDIET-HTA study was a multi-arm parallel, a randomized, single-blind controlled experimental trial comparing the effects of 16 weeks of different aerobic exercise programs two days per week, and dietary intervention in a hypertensive, overweight/obese and non-physically active population. Aim To evaluate the influence of diet and aerobic exercise program intervention on cardiovascular risk (CVR) factors and predicted CVR and vascular age (VA) profiles in overweight/obese people with primary hypertension (HTN), and to analyze the potential sex differences in the ability to predict VA and CVR via different methods. Methods The CVR and VA determined (n = 167, 53.7 ± 7.8 years) using the Framingham Risk Score (FRS) and the new equation for the prediction of 10-year atherosclerotic cardiovascular disease (ASCVD) risk, before and after the 16-week intervention period (different aerobic exercise programs + hypocaloric diet). The sex-specific risk factors considered were age, high-density lipoprotein cholesterol (HDL-C), total cholesterol, systolic blood pressure (SBP), diabetes mellitus (DM) and smoking status. Results From baseline to follow-up, participants reduced (p ≤ 0.001) FRS-CVR score and VA, and SBP. Total cholesterol decreased significantly, but specifically in men (p ≤ 0.001), and antihypertensive medication (%) in women (p = 0.047). No significant differences over time were observed for HDL-C, smoking, DM overall for either sex. For ASCVD-CVR there was no overall change or for either sex. After the intervention, women had a lower CVR score than men (p ≤ 0.001), irrespective of the calculation method. Conclusions The improvement in CVR factors after 16-week lifestyle changes reduced the risk of suffering a cardiovascular event in overweight/obese adults with HTN through the FRS estimation tool, but not with the ASCVD score. The risk score algorithms could underestimate CVR in women. In contrast, VA could be a useful and easier tool in the management of individuals with CVR factors.
DOI Link: 10.1007/s40292-018-0281-0
Rights: This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. This is a post-peer-review, pre-copyedit version of an article published in High Blood Pressure & Cardiovascular Prevention. The final authenticated version is available online at: https://doi.org/10.1007/s40292-018-0281-0

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