Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/29134
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: The lived experience of interferon-free treatments for hepatitis C: A thematic analysis
Author(s): Whiteley, David
Whittaker, Anne
Elliott, Lawrie
Cunningham-Burley, Sarah
Keywords: Antiviral agents
Hepatitis C
Interferon-free
Lived experience
Qualitative research
Therapeutics
Issue Date: Dec-2016
Citation: Whiteley D, Whittaker A, Elliott L & Cunningham-Burley S (2016) The lived experience of interferon-free treatments for hepatitis C: A thematic analysis. International Journal of Drug Policy, 38, pp. 21-28. https://doi.org/10.1016/j.drugpo.2016.10.013
Abstract: Background International discourse concerning the evolution in hepatitis C virus (HCV) therapy has tended to focus on improving outcomes, shortened treatment length and reduced side-effects of interferon-free regimens. How these treatments are being understood and experienced by the people receiving them has so far been overlooked. This study therefore aimed to explore the lived experience of individuals taking interferon-free HCV therapies. Methods Data were generated through 16 semi-structured interviews with a purposive sample of eight participants, recruited from a university hospital in Scotland. The interviews took place between June 2015 and March 2016, before and after a period of interferon-free HCV treatment. The data were interrogated using a thematic analysis, underpinned by social phenomenological theory. Results Three overriding themes were identified. ‘Expectations and realisations’ characterised the influence that interferon continued to cast over interferon-free treatment, contrasting the practicalities of taking interferon-free therapy with preconceived notions. ‘An honour and a pleasure’ portrayed a positive experience of an undemanding therapy, yet among those with a history of drug use, was also positioned as a privilege, associated with feelings of luck and guilt. ‘Treatment needs’ illustrated the strategies participants used to search for treatment efficacy, and the value those with a significant history of drug use placed on support. One nonconforming case is then discussed to enhance rigour and trustworthiness. Conclusion This is the first qualitative exploration of the experience of interferon-free HCV treatment reported globally. The results from this study suggest a cultural lag exists between the pharmacological developments which have been witnessed, and societal understandings of them. This has implications for the way services meet the needs of, and offer therapy to, HCV positive individuals.
DOI Link: 10.1016/j.drugpo.2016.10.013
Rights: Accepted refereed manuscript of: Whiteley D, Whittaker A, Elliott L & Cunningham-Burley S (2016) The lived experience of interferon-free treatments for hepatitis C: A thematic analysis. International Journal of Drug Policy, 38, pp. 21-28. DOI: https://doi.org/10.1016/j.drugpo.2016.10.013 © 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

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